Dr. Eric Nestler: Sex Differences in the Molecular Basis of Depression

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Presented during the Society of Biological Psychiatry 73rd Annual Meeting in New York on Thursday, May 10, 2018
  1. Society of Biological Psychiatry SOBP
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What an informative talk. Our lab uses a post-weaning social isolation model and I have always wondered how that compares to the maternal-separation model. I also wonder about the mechanisms behind the protective effects of post-weaning environmental enrichment. Are enriched environments acting on epigenetic mechanisms of different sets of genes that are responsible for lowing the likelihood of "bad" epigenetic changes like those implicated in neuropsychiatic disorders like addiction, depression, or PTSD? Or might the enriched environment be influencing the same sets of genes/their mechanisms of expression in different ways to make them somehow more resilient to their respective "bad" modifications? Thanks for the food for thought Dr. Nestler and SOBP!

tjwukitsch