Structural variation is a key driver of relapse and aggressive clinical behavior in multiple myeloma

Although they play a role in resistance to treatment, very few single nucleotide variants (SNVs) and insertions/deletions (InDels) are drivers of the progression of multiple myeloma (MM). Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone Health, New York City, NY, discusses structural variation, identified by whole-genome sequencing (WGS), and highlights that complex structural variants deregulate multiple genes simultaneously, providing a novel mechanism driving relapse and disease progression in myeloma. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

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