Enzymes: Nature's Factory Workers

What are enzymes? Why they're nature's little factory workers. They chop up certain things! They build up others! Pretty amazing the kind of chemistry nature can do given enormous polypeptide chains with unfathomable variability and billions of years of evolution, no?

Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!

[ProfessorDaveExplains]

Whoopsie! At 1:07 that should say 98 Fahrenheit, not Celsius! Boy would that be trouble.

[SKyoto]

At 1:19 the video shows 98°C for body temperature. I mean °C or Kelvin is the way to go but it would be 98°F or in the proper metric system 36.67°C.

[joaojose]

I'm a Brazilian student of Biological science, and I am trying to learn english. So, your videos help me a lot, cause I hear of a contents that I like at the same time that I try to understand your leanguage.

[apollopercytiels]

You explain better than my biochemistry professors 90 minute lectures. You’ve been my saving grace since I found you for organic chemistry😭👍

[lukepereira]

Enzyme binding is no longer recognized with the "Lock-and-Key" hypothesis. This is because the active site is not a perfect complement to the substrate. You do not want your enzyme to bind too tightly to the substrate or you might get stuck in the ES complex. This is to say that the difference between the transition state and a tight ES complex would be too high. Think of it more like a sock and a foot where the enzyme (like a sock) can mold to the size of the foot and thus decrease the Free Energy (G) of the ES transition state.

[ericheine]

One of my undergraduate degrees is in Biochemistry. It's really nice to have this as a review. I think Dave's presentation is better than the one I got at UC Davis. Thanks Dave.

[OkKhaos]

A long time ago, I made a comment about how I disliked your teaching style, since it seemed as if you were reading off of some sort of prompter and weren't genuinely involved in teaching the subject. I now understand how difficult it is to put together a flawless presentation and still try to remember it all, so I commend you for that. I appreciate all of these videos because I really have learned a lot from them. Thank you professor Dave!

[thenightdances]

Thank you SO much! I don't know what I would do without your channel! You help me get through Biochem in undergrad and now you're helping me with the MCAT!

[Lilithotw]

These videos are so unbellivvably helpful especially for me in my third college year. Thank you for everything you do

[SeriousStudent]

enzyme is a type of protein tht does catalytic functions in the body. enzymes catalyze biochemical rxn.
1:48. 3:15 enzyme break down molecules. 3:39 stereo specific. 5:10. 5:58

enzyme sometimes needs cofactors (metal ions) OR coenzymes (vitamins) to function properly. they bind to enzyme, and then E binds to substrate.

[johannahorns]

Apart from some mistakes it´s well explained. Ligases and Lyases both cleave and combine molecules, for an enzyme always catalyses the reaction foward as well as rewind. The difference is that a Ligase needs energy for example from ATP and the Lyase doesn´t. Furthermore there was a mistake about the Coenzymes and Cofactors. Cofactor is the generic term for Coenzymes and Prosthestic groups. Coenzymes are molecules the bond only for the short moment of reaction while prosthetic groups are bond covalently to the enzyme. It has nothing to do with the type of molecule or ion. The ion you´ve described for example is a prosthetic group.

[Blank_spce]

I recently failed my first biochemistry test. I hope that watching these videos along with reading my chapters can help me get a much better grade on my next test. Kinda anxious tbh

[tallmikbcroft]

Love your opening. Thanks for helping me study for my biology test

[jollyjokress]

the residue in the active site part - that was hella interesting!

[xx_rikart]

Your lectures are the reason im curious and excited to know more

[ct_hub]

Thanks you are a life saver. I wouldn't have known how to write my Biotechnology test (BTH204) without you.

[ulanjaherbert]

wow, this is an awesome explanation I never expected. God bless you, Professor Dave.

[tj]

Hey Dave. Love your videos. I have one small complaint though. Somewhere around 1:12 you say "...and using only the reactions it has stumbled upon by blind chance." Being a Microbiologist (grad student, so still in school) I understand what you mean here, but technically its not 100% accurate and the statement can be used to sow confusion. I was a young earth creationist until I was 23 years old (34 now), and back then I would have jumped on this statement as a means to justify my distrust of the theory of evolution. Your recents 'debate' opponent, Ken Hovind, who was a hero of mine back then, loves these statements. The thing is, natural selection is not blind chance. Mutations are, but natural selection is not and, correct me if I am wrong, but these enzymes are the product of natural selection over time. Anyways, thanks for doing what you do and keep up the good work!

[Shenodien_uu]

Thank you so much for your efforts to make up this video, I am a student from Egypt and you are really helping me with your videos in studying, keep going Mr Dave 👏💛

[haykt]

you're the best thing to every have happened to you sincerely for all your videos