What is Size Reduction= Process of Size Reduction in Pharmaceutical Engineering.

Size reduction is a process in which the particle size of a solid is made smaller. The term size reduction is applied to ways in which particles of solids are cut or broken into smaller pieces. Size reduction is necessary if the starting material is too coarse, and the final product needs to be a fine powder. Importance of Particle Size Reduction

The process of size reduction is commonly employed in pharmaceutical industries due to the following reasons: (1) To increase the rate of the solution in case of chemical substances, because the reduction of the particle size increases the surface area for the action of the solvent. (2) To allow the rapid penetration of the solvent (menstruum ), in case of crude drugs for the extraction of active constituents from vegetable and animal drugs. (3) To get a uniform powder because particle size reduction helps in uniform mixing of drugs, required for preparing different formulations for administration. (4) To increase the rate of absorption of a drug. The smaller the particle size, the greater is the rate of absorption. (5) To improve the stability of certain pharmaceutical dosage form, such as suspensions. The rate of sedimentation decreases to a large extent by reducing the particle size of the drug. (6) To help in the process of separation of solids from liquids by filtration or by sedimentation. The rate of filtration or sedimentation depends upon the particle size.

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[omprakashnirnejak]

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[jyothikollur]

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[qclaborganization]

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[omprakashnirnejak]

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