What is Normal Endometrial Thickness for Frozen Embryo Transfer?- Dr.Shipra Singla | Doctors' Circle

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Cloudnine Hospitals, Patparganj, New Delhi
Endometrium is the innermost lining of the uterine cavity. So it has two components one is basal layer. Other is functional layer. So basal layer it has a tendency to regenerate the functional layer. So what happens in a one particular menstrual cycle of a female. So the functional layer under the hormonal influence it gradually thickens so that it helps in the implantation . But if the pregnancy does not happen this functional layer it sheds off where the hormones declines in the menses. So for pregnancy to happen ideal endometrium thickness. We take it is almost 7 to 8 mm. So when we prepare patients for the amb transfer in any IVF cycle there are many protocols involved and we select the patients and whatever protocol is is best we prepare the endometrium lining accordingly. So these protocols could be hormone replacement therapy. Here we start the patient on estrogen therapy from Day 2 or Day 3 of the period we give estrogen in gradually increasing doses till the lining reaches 7 or 8 mm. Once the lining reach is 7 to 8 mm so minimum we give estrogen for at least 10 days. So once lining reach is 7 to 8 mm then we start progesterone. Day three or day five before amb transfer depending whether we are transferring day three embryo transfer or blastocyst transfer. We are doing another protocol is down regulated HRT cycle. Here before periods we down regulate the pitutary gland with the help of some injections or some medication and from day two we start the estrogen therapy and once the lining reaches Optimum size like 7 to 8 mm then we give the progesterone 3 or 5 days prior to the embryo transfer. Other could be the modified natural cycle or even sometimes we can do natural cycle embryo transfer. Here we follow the menstrual cycle of the female with the help of ultrasound and hormones and once the lining is suitable we do the embryo transfer.

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