Illumina AI - ChatGPT for your genome...

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TIMELINE
00:00 Advancements in AI
00:25 AlphaFold2
05:24 Increasing Interest
08:34 Illumina's PrimateAI 3D

So Illumina unveils AI software to predict disease-causing genetic mutations in patients.

The AI boom has been mostly centered around the big AI companies NVIDIA, GOOGLE, MICROSOFT, OPENAI etc

That’s the space that everyone is watching. That’s where all the institutional money is flowing, but there is something else brewing just out of sight.

First, it’s important to understand how Google’s DeepMind solved protein folding.

And people are noticing this.

More and more attention is being paid to the biotech companies where neural networks can be used to accelerate progress.

People in this space believe that massive progress will be unlocked at the intersection of AI and Genetics.

Neural Networks are great at swallowing large, unmanageable amounts of raw data and spitting out valuable insights.

And that’s what a big part of Genomics is. It’s vast amounts of data.

That brings us back to Illumina.

It’s a massive company that is a global leader in genomic sequencing.

Genomic sequencing, is very basically, the process of making DNA readable.

So let’s say you have a blood sample or a spit sample, you run it through a machine to sequence it and on the other side you get the exact structure of your DNA.

Actual data you can read, print out on a piece of paper or feed into a database.

And there are now global efforts to sequence everyone and use AI to process the data.

And some smart people are taking note

Peter Thiel is a German-American billionaire entrepreneur, co-founder of PayPal, Palantir Technologies, and Founders Fund, he was the first outside investor in Facebook.

And he’s investing in Ultima genomics, a competitor to Illumina.

“Ultima Genomics is coming out of stealth mode after raising $600 million from investors including Andreessen Horowitz, Peter Thiel’s Founder Fund…”

This was in 2022

Carl Icahn, the billionaire corporate Raider launched an attack on Illumina, buying up shares and trying to land some board seats.

This was 2023

Stanley Druckenmiller, who is considered one of the best investors of all time, recently added $25 million of Illumina to this portfolio.

This was May 2023, but this might be a lot more since there is a delay before they have to disclose their positions.

Now, a couple of points I have to make here.

One I own Illumina Shares, full disclaimer.

Two, I can’t predict stock price, I don’t pay attention to the price.

I just think “what would Warren Buffett do” and buy great companies and hold them forever.

With that said, I feel like we are going to start seeing more action in this space.

Bio-tech, specifically bio tech where AI can play a big role, will start growing at a faster rate.

Genomics, personalized medicine, modified organisms etc.

[Lemurai]

A team of pharmacologists, biochemists & engineers already worked out the concept of this back in 2000, now that the theory is in place, any company with machine learning capabilities can apply it.

[rinzler]

So basically AI will take us one step closer to gene engineering ourselves. Solving disease, cancer, Alzheimer's or even engineer ourselves aesthetically once we've mastered it. Im all in i want blue eyes

[celestinian]

It's the field of AI that will solve the problem of cancer in the end

[RickeyBowers]

Many meaningful discoveries are on the horizon. More discovery and powerful tools will enhance our understand of the language nature writes software in. It's important to emphasize how successful and pervasive this software is! The programs nature evolves operate in the physical reality. Understanding that is not just a revolution in biology, but also in nanotechnology.

[alexguilherme]

Holy shit, i was working in this for a long time now, this is just glorious that our most briliant experts finaly gave a chance to combine the power of AI and biology

[carlitosway]

so basically we can now grow back arms and legs that were missing

[jcfnetwork]

so interesting thanks for covering this more niche application of AI I had no idea about a lot of this stuff

[msidrusbA]

solving autoimmune disorders with a gene therapy program would revolutionize many chronically ill people's QOL. among other insane things, ai driven innovation in the medical field/genes is going to be a two sided coin for humanity to toy with. good or bad im rooting for it.

[scottlacey]

Hi Wes. Bro, I like you and I like your videos. I just watched the one on tool making using gpt3.5 and gpt4. I loved it and think its very practical. And i like your insights. But a couple of things, possibly controvertial, eg. (if climate change and carbon emmissions in general were a money making scheme - which i believe, and on top of this, diabetes, hypertension, obesity were the product of greedy sugar companies - knowing ful well sugar is a chronic toxin but dont care), and here back to the video, the key point at the end was solving the complicated dilemna of diabetes. and also the actual promotional video by deepmind alphafold said they want to solve climate change. it just strikes me as a tradgedy that these people are just pointing these powerful tools at making money, and ignoring the truth. But i do love the toolmaking. and i honestly kind of agree with your insights. God bless mate. Scott

[stephenjimenez]

All good with the exception of access to the tech, which historically has been denied to those below, an or who are not part of the ‘in-group’. Eugenics related policy has become the unspoken drive for those who continue to seek to control the wealth, and thus access to the most valued commodity, (which is information).

[louielouie]

Build Chloe .Build me a pair of Chloe's. The tech is here. We just need to start building agents to begin innovating it's own biological make up and use it to teach us how to do the same. Imagine the possibilities of an open source think tank of that magnitude. If only we had the balls to collectively make it happen right?

[louielouie]

Every input has an output component. So any electrical scan can also project yet we are all baffled about why technology hasn't caught up to Utopian levels.
This technology has been in use commercially since 1995.

[cmiguel]

I want a mullet, six pack and a bigger ... nevermind.

[wonkyfug]

Oh look, pharma companies don't have an excuse to not release things now, because someone will just figure it out.

[jamesgrey]

Ultima? Illumina? Did these people play too much Final Fantasy 6?

[wood]

Does the electron repulsion of a proteins molecular configuration act as a limiter to what shapes it can fold into or act as a shortcut/driver for the shape it ultimately settles into?

[riftvideos]

as someone who is playing with small models for fun and seeing the difference a little more power gives, i am stoked someone is putting that much juice into diabetes and such.

[metakron]

I can't wait to have biological superpowers similar to x-men 😉

[Puerco-Potter]

Hqve you watch the movie GATACA? This is how it starts...

[sbam]

This needs much more ethical, cautious approach, checks and balances, much more than AI, generating unknowns to ensure potential irreversible cock-ups leading to 🤷‍♂️☠️