TWiV 596: COVID-19 – an ounce of prevention

TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more.

[bitsandpeace]

I'm a retired engineer and I love your podcasts - my brother is still practicing M.D. with a couple specialties and he also loved learning of your almost daily podcasts - thank YOU! and all your guests for all you all are doing - you people in the trenches are true heroes and heroines !!! Our country will be forever in your debt!!!

[michaele.]

Cov patients need a CBC as well as a chemistry (basic metabolic) panel and nutrient serum test for Zinc K and D.

[therombaro]

16:05 - FDA EUA for HCQ and CQ
18:35 - the studies
19:40 - about the papers, culturing vs PCR
20:45 Wuhan trial
22:45 peer reviewed NEJM Seattle
24:00 convalescent plasma
25:06 Ribovirin
28:55 Blood supply and blood donation
30:50 - Rapid test
31:40 - Lupus patient letters about HCQ scripts being canceled
32:35 - Sensitivity of HCQ prescription for Lupus
34:50 - Hong Kong blood tests
36:10 - Distinguishing recent vs previous infection with tests
38:10 - How rapid tests work
39:50 - can the virus mutate out of our immune response (antigen shift)
41:30 - Gas pumps
45:00 - No Cross protection between SARS 1 and 2
46:50 - copper inserts for masks
48:25 - Open standards for PPE
50:00 - Do languages produce different aerosols?
52:15 - Can you be removed from a ventilator for it to be given to someone else?
55:45 - Innoculum size in HCWs
59:35 - where are new infections coming from?
1:01:15 - discharge standards for patients
1:03:40 - Fauci’s models and inaccuracies
1:06:30 - Herd immunity
1:10:30 - N95s
1:13:06 - Why infectious dose is not important for young patients, and why Covid is less serious in young patients.
1:18:10 - Using CPAP machine in place of ventilators
1:20:25 - why fever reduction matters
1:23:25 - calculating closed cases
1:25:25 - IL6 mitigating response
1:27:50 - Coitous
1:29:20 - PPE sterilization

[ellyess]

Loved it when you said everyone is important in healthcare! This week I wrote on my rubbish/garbage bin lid "Thank you Bin Men, You're the first line in our Health Care" . If they stopped, the rubbish piling up would lead to vermin, disease... My Bin Men are so friendly and helpful too. I'm in Bramcote 4miles outside Nottingham UK.

[MrOzzyCam]

Thanks for another great episode of TWiV. I already listened to it on microbe.tv it is well worth a listen!

[niftyrosa]

I never claim to know everything, I keep it to myself. Thank you for the free lessons!

[iashakezula]

TWIV helps me with my sanity . Thank you Doc Racaniello.
But damm Kaiser.
Speaking of sanitizer, Thank goodness I bought some hand sanitizers in different container back in February and hand wipes, Lysol spray and wipes, my husband should thank me for thinking ahead and he has not said thank you 😠 and being an OR nurse I have been enforcing disinfection practices and not allowing out side clothes shoes in the house proper and placed big air purifiers in the bedrooms and den and washing raw produce.

We have to watch out for our copper pipes 😆
About talking, yeah there was a test in Japan and it showed micron sized droplet by talking
My former nursing classmates who are in NY has posted on messenger and the ones intubated are mainly DNR

[mnoxman]

Cross protection among other corona viri. How about Canine CV? Has anyone checked up on the Veterinarian group to see if they are getting CovD-19 at higher or lower rates?

[brijmohanmalvi]

Any idea about steam inhalation in acute stage of COVID19???

[阿牧药理]

Anyone test inflammasome NLRP3 inhibition drugs such as OLT1177(dapansutrile) for SARS-CoV-2 induced cytokine storm? There are a lot of NLRP3 direct and indirect inhibitors, some are natural products which are safe to use.

[AV-nfxd]

The email response about COVID antigentic drift didn't age well.

[josephstlouis]

I had dengue fever recently. On November 4, 2019 I was tested and had tested positive for Dengue IGM and IGG.
Also I tested positive for Dengue antigeno NSI
Is this going to help me, cross protection, or hurt me if I get covid-19?
Thanks for Podcast from Guatemala.
Chuck

[whoever]

I read somewhere that there could be a risk of aerosolizing the virus using a CPAP, but I can't remember for the life of me where I read that. I do know that it was from the scientific community and not some random person making the hypothesis. Of course, if the choice is aerosolizing the virus and possibly saving a patient's life, you try to save the patient's life.

[harbinguy]

3:35 "Vincent: today (4/2/2020)we are at 100K, I think we will over a million, easily".

[dianahwang]

Question about coronavirus deaths not being reported: To what extend are medical examiners searching or required to search for coronavirus when doing autopsies deaths on people who died suddenly in their homes? I heard they may not because test kits are being saved to test living people.

[Grandpa]

I'm a few days in the future from you. IHME is the site Dr Brix uses in her presentation.

[drnaveed]

I know we all are looking for treatment of Coranavirus but so far there is only one treatment and that is to improve the care system of infected people especially who develop viral pneumonia. All other trick we hear on internet are not working on seriously ill patients with coronavirus.

People are recovering due to immunity and we can give that credit to anything we come across.

[SurlyHick]

To wear a mask or not wear a mask: the virus can be passed from a person without symptoms/signs. The viral load is not know as we can’t test by infecting people. The NIH has a study from 2008 describing the efficacy of using even homemade masks. It’s not just prudent, but urgent that mask wearing becomes standard ASAP.

[whoever]

I imagine sign language would be the safest language, although I think you just want to stay away form people for the most part.

[HotelPapa]

As Italians speak a lot with their hands, I dunno about the language thing ;-)
The practice in English to produce 'L' with your tongue sticking out can't be safe, though. :-P