Current and Emerging Treatments for IBD

Watch this video to learn about medications used in the treatment of Crohn's disease and ulcerative colitis, including 5-ASAs, immunosuppressants, steroids, biologics, biosimilars, and other emerging treatments for IBD in Canada. Find out from an expert gastroenterologist how these medications work in IBD, what they are used for, which types of patients can access these medications, potential benefits, side effects, and risks. Other topics include minimizing steroid use, discussing treatment goals with healthcare providers, and the role of treatment in promoting mucosal (gut) healing.
The Gutsy Learning Series is supported by AbbVie and Takeda.

0:00 Introduction and upcoming events
4:16 Poll questions to audience
7:29 What is IBD and what does it look like?
7:56 IBD epidemiology and impact in Canada
9:34 Goals of treatment and the importance of mucosal healing
12:34 Clinical and endoscopic remission
16:05 Overview of medical therapies for IBD in 2022
19:23 What are 5-ASAs and how do they work?
22:00 What is 5-ASA used for?
23:29 What are the side effects of 5-ASA?
25:22 What are Immunosuppressants and how do they work?
28:00 First reported use of Imuran (thiopurine) for ulcerative colitis
28:22 Who are immunosuppressants used for?
30:51 What are the side effects of immunosuppressants?
32:50 What are steroids and how do they work?
35:34 Who are steroids used for?
36:35 Serious side effects of steroids
38:00 Corticosteroids: safety concerns
39:04 How do you minimize steroid use?
39:50 What are biologics and how do they work?
42:54 Biologic therapies available for IBD
44:50 History of Anti-TNF drug development in IBD
45:05 Infliximab effect on fistulizing Crohn’s disease- case study
45:35 New therapeutic targets
48:18 What are the side effects of biologics?
50:36 Risk of surgery for IBD before and after 2000
51:51 What is a biosimilar
53:52 How are biosimilars different from biologics?
57:09 What are JAK inhibitors?
59:54 What are the side effects of JAK inhibitors?
1:03:16 Upcoming treatments
1:03:53 Maintenance therapy
1:05:00 Combination therapy
1:06:24 Microbial therapies
1:07:20 Nutritional therapies
Q&A
1:10:09 Is the effectiveness of all biologics time limited?
1:11:09 Is there an increased risk of serious complications taking biologics with another medication?
1:12:53 How can you deal with the burning from Humira injections?
1:14:44 During remission, can you stop taking 5-ASAs and take them again once there is a sign of flare reoccurrence?
1:15:52 Is it okay to take supplements or weight loss pills while also being on biologics?
1:17:03 Is it possible to develop side effects to a medication several years after starting it?
1:17:54 Are side effects different for older adults and younger individuals?
1:19:34 If tried multiple biologics and they all eventually failed, what can be used next?
1:24:49 If on biologics and in full remission, is it wise to get off biologics and take another medication?
1:26:38 Can the same biomarkers used when testing for IBD disease severity help inform response treatment?

Speaker:
Dr. John K. Marshall (MD, MSc, FRCPC, CAGF, AGAF), Professor of Medicine, Director, Division of Gastroenterology, McMaster University

[MissMarceline-wpoq]

Are you trying to kill the patient with combining biologics with imuran.

[mrpoate]

Really helpful talk (especially the bits about surgery risk pre & post 2000, as well as some of the history around biologics). Thanks :)

[sineater]

This was very informative. Thank you.

[michaelkurbah]

excellent in lecturing the theory only but practically no idea or single words for cure .fake doctor sweet words only .shame on you