Stress-Responsive Common Genetic Variants Predict Risk of Psychiatric Disease

Using a stimulated eQTL approach, J. Arloth et al. show that common genetic variants that alter the initial transcriptome response to stress hormone receptor activation also cumulatively increase the risk for stress-related psychiatric disorders and predict a threat response from the amygdala.

J. Arloth, R. Bogdan, P. Weber, G. Frishman, A. Menke, K.V. Wagner, G. Balsevich, M.V. Schmidt, N. Karbalai, D. Czamara, et al. (2015). Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron 86.