Electrochemical Arene C-H Amination with Dr. Eva Maria Alvarez

In this Research Spotlight episode, Dr. Eva Maria Alvarez joins to share her work on electrochemical arene C – H amination (Malapit group).

Version in Spanish:

Key reference:
J. Am. Chem. Soc. 2024, 146, 3591-3597.

Other references (in order of appearance):
For selected examples of aromatic C – H amination in medicinal chemistry, see: J. Med. Chem. 2016, 59, 4443–4458; Nat. Chem. 2018, 10, 383–394; Chem.Rev. 2022,122, 1925−2016; Chem.Rev. 2023,123,11269−11335.
For pioneering work on electrochemical C – H amination, see J. Am. Chem. Soc. 2013, 135, 5000– 5003; J. Am. Chem. Soc. 2014, 136, 4496–4499; J. Am. Chem. Soc. 2015, 137, 9816–9819.
For selected examples of photocatalytic generation of aminium radical cations for aromatic C–H amination, see: Nat. Chem. 2019, 11, 426–433; Angew. Chem., Int. Ed. 2019, 58, 526–531; Angew. Chem., Int. Ed. 2019, 58, 532– 536. For radical-cation-pi interactions found in nature, see: J. Am. Chem. Soc. 2010, 132, 11812–11823; Phys. Chem. Chem. Phys. 2011, 13, 16698–16705.
For pioneering work on anodic oxidation for C – H amination, see J. Am. Chem. Soc. 2013, 135, 5000– 5003; J. Am. Chem. Soc. 2014, 136, 4496–4499; J. Am. Chem. Soc. 2015, 137, 9816–9819.
For selected examples of Fukui indices calculation, see Nat. Chem. 2016, 8, 810–815; J. Am. Chem. Soc. 1984, 106, 4049–4050.
For selected examples of charge-transfer complex formation in e-chem, see J. Am. Chem. Soc. 2018, 140, 12511–12520; Org. Lett. 2021, 23, 454−458.
For selected examples on reactivity of quaternary ammonium salts, see Org. Lett. 2022, 24, 4170–4175; Org. Lett. 2018, 20, 6389– 6393; J. Am. Chem. Soc. 2020, 142, 1603–1613.