Advancements in clinical trials for high-risk newly diagnosed multiple myeloma

Lisa Leypoldt, MD, University Medical Center Hamburg, Hamburg, Germany, discusses advancements in clinical trials investigating treatment approaches for high-risk newly diagnosed myeloma. The GMMG-CONCEPT (NCT03104842) and OPTIMUM/MUK Nine b (NCT03188172) showed high response rates to combination treatment in this patient population. Dr Leypoldt also mentions the CARTITUDE-5 (NCT04923893) and CARTITUDE-6 (NCT05257083) trials which are investigating ciltacabtagene autoleucel (cilta-cel) in the first-line setting, although these are not dedicated high-risk trials. This interview took place at The 10th World Congress on Controversies in Multiple Myeloma (COMy) in Paris, France.

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