Advances in the science and treatment of MPNs

Ruben Mesa, MD, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, gives a detailed overview of recent advances in the treatment of myeloproliferative neoplasms (MPNs), including ongoing clinical trials and novel agents. Dr Mesa first highlights novel therapies being developed for essential thrombocythemia (ET) and polycythemia vera (PV), including ropeginterferon, and ongoing trials in this area. Dr Mesa then discusses the promise of novel agents such as rusfertide, and further explains advances in the use of various JAK inhibtors for the the treatment of myelofibrosis, including fedratinib, pacritinib, and momelotinib. To conclude, Dr Mesa highlights the importance of novel combination therapies and their role in the future of MPN treatment. This interview took place at the American Association for Cancer Research Annual Meeting in New Orleans, LA.