Nicholas Banovich - Spatial genomics to dissect the molecular underpinnings of pulmonary fibrosis

"Using single cell and spatial genomics to dissect the molecular underpinnings of pulmonary fibrosis"

The Banovich Lab is focused on understanding how gene regulatory changes alter disease risk, progression and treatment response. The lab employs a combination of experimental and computational approaches, integrating molecular biology, genomics and computational biology. We specialize in generating and analyzing multi-omic datasets, with a particular focus on identifying genetic variation associated with changes in gene regulatory phenotypes. Aided by novel single cell genomic technologies, our research continues to move towards profiling gene regulation at cell-type resolution. Our lab also heavily relies on a team science approach, coupling our expertise in functional genomics with researchers and clinicians with domain expertise in specific disease areas and human populations. By studying gene regulatory changes in relevant tissue samples, at cell-type resolution and in the proper disease and treatment context, we are well positioned to make a translational impact.