The Shocking Link Between Inflammation and Heart Attacks: Inflammation and Atherosclerosis

This animated video shows the role of inflammation in atherosclerosis, which is the primary cause of heart disease and stroke.

Inflammation plays a critical role in the development and progression of atherosclerosis, which is a condition in which plaque builds up in the walls of arteries and can eventually lead to heart disease and stroke.

When the inner lining of the artery (the endothelium) is damaged, immune cells such as macrophages and T cells are attracted to the site of injury. These immune cells release cytokines and chemokines, which are signaling molecules that trigger an inflammatory response.

As inflammation persists, white blood cells and lipids, such as low-density lipoprotein (LDL) cholesterol, accumulate in the arterial wall and form fatty streaks. Over time, these fatty streaks can develop into more advanced plaques that narrow and stiffen the arteries, which reduces blood flow and increases the risk of cardiovascular events such as heart attacks and strokes.

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[jeffinTN]

This video fails to explain what causes the vascular endothelial cells to express adhesion molecules and causes the change in permeability of the arterial wall. I would suggest these are caused by elevated sugar levels, the primary cause of vascular inflammation.