Thrombotic Thrombocytopenic Purpura (TTP)

Hemolytic Uremic Syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure.

Thrombotic thrombocytopenic purpura (TTP) is a pentad of microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure, fever, and neurological abnormalities. Thrmbotic microangiopathy (TMA).

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Bernard-Soulier Syndrome (BSS) is an autosomal recessive (AR) disorder characterized by a defective GP1b platelet receptor leading to a problematic platelet adhesion process (primary hemostasis).

Glanzmann Thrombasthenia (GT) is an autosomal recessive defect in the GPIIb/IIIa (GP2b/3a) receptor on the platelet which leads to defective platelet aggregation.

Ristocetin Cofactor Assay (RIPA) is usually abnormal in cases of Bernard-Soulier Syndrome (BSS).
Bleeding time is prolonged, platelets are big in size, but few in number (Macrothrombocytopenia).

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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).

Bleeding 🩸 time (BT) is another test for platelet function.

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[medic-]

Love the Gordon Ramsay monologue at the end 🤣

[Sammy.a]

Coombs test is negative because although the IgG antibodies are present, they are not against RBC's or platelets, they are against the enzyme which breaks down vWF.

[PedramV]

I was diagnosed with TTP a couple of weeks ago. Still in the hospital, but PEX got things in order (the last one was three days ago). This video was extremely helpful and helped me understand what's happening to me. Thank you!
Btw, they suspect I might actually be one of those extremely rare cases of inherited TTP. Gotta start buying lottery tickets 😂

[dayo.s]

Wow loved how you explain everything in details and you repeat the important things more than 1 time.

[cjodyssey]

9:59 "i dont care nerd" will now be my response when the attending trys to pimp me

[siddharthtrivedi]

You made medicine super fun whilst givin proper info. Thanks . Subbed!

[princevegeta]

The unique and funny way of explaining stuff and the way tough topics are broken down into easy and digestible bits are a boon to have, before exams.

Keep up God's work good sir!! Left you a like❤

[cheffinitupwithmrpossibili]

currently an img studying for my step 1 and this video gave me a much clearer understanding of TTP!

[jameslazib]

love the energy you're bringing hahah

[msdreirae]

OMG I love this so much! thank you. i just started working in hematology after working for years in onco and ITU. I was having a hard time making patterns and organizing my studies. this extremely helps! thank

[shreyaray]

Ahh this was so much fun. Where was this channel all my life!,

[timiahgallishaw]

I currently have ttp but I’m fighting I will get through this !!

[Besmaht]

so entertaining and educational. i didnt fall asleep once

[drbonfire]

"you need to know what the flip you are talking about" hahaha fortunately that is the reason I am here good sir

[s.u.k.k.u]

I thought i will watch the pathology of TTP only and skip the rest video…but crap i got Stuck 😂😂😂
Your videos are extremely helpful n fun to watch. 🙂

[nightstar]

Hello, doctor
I have one question. In TTP, vWf is overly active, platelets are adhered to form a thrombosis and the number of circulated free platelets decrease. In Bernard Soulier disease vWf is normal but receptor is inactive. It doesn't adhere to form thrombosis. So, they should be circulated freely through the bloodstream .But why, platelet number decrease instead of increasing ?

[amarbhagat]

Data - information- knowledge- wisdom great bro💥💥💥💯💯❤️

[nninnne]

I love you man u literally saving my life .

[rrrrrrrrrrrf]

Keep it up ❤❤
But why is the quality so bad 😢

[shahabuddin]

Wow really you're all material is very conceptual, thanks sir keep it up, be happy and healthy forever