Tissue Engineering in Restorative Dentistry

Tissue Engineering in restorative dentistry
The Tissue Engineering Revolution. The Future of Tissue Engineering in Restorative Dentistry
Regeneration cell based strategies. ● Types of Stem Cells. ● Sources of stem Cells for Odontogenesis. ● Teeth Regeneration can be broadly divided into Several areas. ● Major Obstacles faced for clinical application of stem cells dental tissues regeneration.
What are stem cells ? Stem cells = Raw Cells
Why it’s important to know about them? Nowadays, the missed teeth are replaced by dentures, bridges or implants. Despite implants are the most favorable choice of treatment. 크라운 브리지 치아
new biological solution represents biological tooth. precisely regenerated. and reintegrated into the jaw of human patient with tooth loss
bio-tooth based on cells is not realistic yet, and before doing two main things should be resolved
Regeneration. (A cell based strategy).
Morphogenic signals such as growth factors and differentiation factors: ✔ In body, there are cytokines and BMPs (Bone Morphogenetic Protein)
Dentally, GDF/11 (Growth /Differentiation Factor 11.
Regenerative Dentistry Synthesis Lectures on Tissue Engineering
which is a member of BMPs family,
differentiates dental pulp stem cells into odontoblast, this differentiation is cornerstone in teeth tissue engineering
Scaffold of extracellular matrix:
Cells are categorized by their source: 1. Autologous cells . 2. Allergenic cells
3. Xenogeneic cells .4. Syngeneic or isogenic cells
undifferentiated cells
specialized cells
Adult( somatic),multipotent. 2. Embryonic ,pluripotent. 3. Totipotent, earliest stages of the embryo. Stem cells
embryonic stem cells
grow new organs.
dental ectomesenchymal cells
dental pulp stem cells Emerging Clinical Applications for Hard & Soft Tissue Regeneration
Stem cells from human exfoliated deciduous teeth (SHEDs) • Stem cells from the apical papilla (SCAPs) second group: contain • Periodontal stem cells (PDL) • Dental follicle progenitor cells (DFPCs) 2. Non dental source: • Human bone marrow cells • Animal source and human non bone marrow Sources of stem cells for odontogenesis. synthetic materials for restorative dentistry. 3. Regeneration of cementum as a part of periodontal regeneration. 4. Regeneration of the periodontium cementum, periodontal ligament and alveolar bone. 5. Regeneration or synthesis of enamel like structure. 6. Regeneration of the root. 7. Regeneration dentin chamber. or as a replacement current synthetic materials.

it does not appear case for epithelial stem cell (EpSC). A reliable source of EpSC . ● furthermore, in the case of adults , still remains a problem , dental epithelial stem cells lost after the eruption of the teeth . ● To solve this problem use artificial crown , which will be supported for a teeth originating for the mesenchymal stem cells
Teeth regeneration Tissue Engineering in Restorative Dentistry
stem cells may be useful for the repair of diseased of damaged tissues, new organs. _ somatic stem cells have a limitation in their potential of differentiation. _somatic or adult stem cells are a better option in dentistry, as these cells are easily accessible, and not bring up ethical concerns. _ today practical use of dental stem cells problematic dental stem cells restricted to specific points in time. _bone marrow derived mesenchymal stem cells
Teeth regeneration . Sample - Generation of Teeth Using Stem Cells
dental epithelial stem cells . eruption of the teeth
artificial crown .
Tissue Engineered Solutions for Esthetic Dilemmas
mesenchymal stem cells
immune rejection risk . What is Tissue Engineering
What does the future hold for regenerative medicine in dentistry
substrate, scaffolds and growth factor
What does future hold regenerative medicine in dentistry
Dental Tissue Engineering Periodontist
major stride. Can we grow a tooth using stem cell
regeneration of pulp,
Tissue-Engineered Solutions for Soft Tissue Defects
PDL,bone, enamel
Dental pulp stem cells
animal model
from orthodontically extracted teeth
Reported that inflamed pulp tissue was an appropriate source for isolation. Inflamed pulp-derived stem cells revealed a capacity for regeneration of the dentine-pulp complex
from intact pulps
dentinogenic cells
necrotic pulp using stem cells
stem cell transplantation
Cells for Tissue Engineering and Regenerative Medicine
Scaffolds and biomaterials
controlled rate of regeneration
regenerative endodontics
Lectures Dentist