InterPro | How To Know About Domain In Protein Structure & Their Function in 5 mins | Bioinformatics

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InterPro is a database of protein families, domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences in order to functionally characterize them.
InterPro provides the world’s most comprehensive predictions by combining predictions from 13 member databases. This webinar defines the basic InterPro notions, concepts of protein classification and describes how InterPro ensures the accuracy of its data. This webinar also explains the different methodologies used by the InterPro member databases in their predictions and how we integrate them into the 5 different InterPro entry types: Homologous superfamily, family, domain, repeat and site. Finally, it presents some examples of different external resources using the InterPro database as an underlying resource.
The contents of InterPro consist of diagnostic signatures and the proteins that they significantly match. The signatures consist of models (simple types, such as regular expressions or more complex ones, such as Hidden Markov models) which describe protein families, domains or sites. Models are built from the amino acid sequences of known families or domains and they are subsequently used to search unknown sequences (such as those arising from novel genome sequencing) in order to classify them. Each of the member databases of InterPro contributes towards a different niche, from very high-level, structure-based classifications (SUPERFAMILY and CATH-Gene3D) through to quite specific sub-family classifications (PRINTS and PANTHER).

InterPro's intention is to provide a one-stop-shop for protein classification, where all the signatures produced by the different member databases are placed into entries within the InterPro database. Signatures that represent equivalent domains, sites or families are put into the same entry and entries can also be related to one another. Additional information such as a description, consistent names and Gene Ontology (GO) terms are associated with each entry, where possible.
#interproscan​ #protein_family​ #protein_classification

[bioinfoxpert]

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[mehwishahsan]

You make things so much easier to learn. Thank you for the efforts.

[carolinej.]

Hello sir, on my result page, there is predictions entry.. what is that?

[zainiiBee]

i am using interpro, but my results arent like yours, it shows the entry matches to Domain of Unknown Function and in that Predicted 3 domains, cytoplasmic, transmembrane and non-cytoplasmic, all with no siginificant pdb match

[shichengguo]

Can we only select to use Pfam only in interprot?

[malihafatima]

There is no domain...only predictions...how can i draw pdb and highlight domains with name in form of diagram as i have to paste it in thesis