Microscope Advance Reveals Subcellular Action

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A team of scientists has been able to significantly increase the resolution of Structured Illumination Microscopy (SIM). By increasing the numerical aperture of these microscopes, and using two different illumination wavelengths to excite subsets of fluorescent proteins, this modified microscopy technique allows researchers to look much more closely into the microscopic world of cells. Already, Nobel prize winner Eric Betzig, Dong Li and their colleagues have used this improved technique to gain a better understanding of clathrins, which help transport molecular cargoes into cells. Their work, which offers new insights into clathrin and cytoskeleton interactions, among other findings, is published in the 28 August issue of Science.