Biochemistry Focus ECR webinar series - Biochemistry: one molecule at a time

This webinar is linked to a special issue with the same title published in Essays in Biochemistry. Biological processes are orchestrated by complex networks of molecules. Conventional approaches for studying the action of biomolecules operate on a population level, averaging out any inhomogeneities within the ensemble. Investigating one biological macromolecule at a time allows researchers to directly probe individual behaviours, and thus characterise the intrinsic molecular heterogeneity of the system. Single-molecule methods have unravelled unexpected modes of action for many seemingly well-characterised biomolecules and often proved instrumental in understanding the intricate mechanistic basis of biological processes.

This issue of Essays in Biochemistry showcases different types of single-molecule techniques and their applications to investigate processes that are fundamental to life. This is also the first issue written and edited entirely by early career researchers who help drive this exciting field of research forward.

At this session we welcome three authors from the issue who provide a sampling of current experimentation using single-molecule techniques and the application of these methods to a range of biochemical problems:
• George Cameron, Francis Crick Institute London (UK)
• Dr Sonja Schmid, Wageningen University (Netherlands)
• Dr Pétur Heidarsson, University of Iceland

The webinar was chaired by Dr Dominika Gruszka, at The Francis Crick Institute and Chair of the Biochemical Society's Early Career Advisory Panel. She is also Guest Editor of this special issue.