Toward Personalizing HIV Treatment and Prevention

Air date: Wednesday, May 4, 2022, 3:00:00 PM

Description:
NIH Director’s Wednesday Afternoon Lecture Series [WALS]
This is the annual Rolla E. Dyer Lecture.

The Dyer Lecture is the oldest continuous lecture series at the NIH, established in 1950 in honor of former NIH Director Rolla E. Dyer, M.D., a noted authority on infectious diseases. The lectureship features internationally renowned researchers who have contributed substantially to medical as well as biological knowledge of infectious diseases.

Dr. Bumpus is director of the Department of Pharmacology and Molecular Sciences and a professor of pharmacology and molecular sciences at Johns Hopkins Medicine in Baltimore. Her lab focuses on defining a role for cytochrome P450-dependent metabolites in drug-induced acute liver failure associated with certain antiviral drugs used to treat HIV and hepatitis C. She has developed novel mass spectrometry assays to measure and discover drug metabolites.

Individual tailoring of antiretroviral regimens has the potential to further improve the long-term management of HIV through the mitigation of treatment failure and drug-induced toxicities. While the mechanisms underlying anti-HIV drug adverse outcomes are multifactorial, application of drug-specific pharmacogenomic knowledge is required in order to move toward the personalization of HIV therapy. Dr. Bumpus will discuss pathways of drug metabolism and provide a detailed understanding of the metabolism of antiretrovirals and the influence of genetics on these pathways.

Author: Namandje Bumpus, Ph.D., Director, Department of Pharmacology and Molecular Sciences; Professor of Pharmacology and Molecular Sciences, Johns Hopkins Medicine