Dr. Eran Elinav on Microbiome Insights into Personalized Response to Diet, Obesity, and Leaky Gut

Eran Elinav, MD, PhD, is a professor of immunology and principal investigator at the Weizmann Institute of Science in Tel Aviv, Israel, where he co-directs the Personalized Nutrition Project. Dr. Elinav is also a principal investigator at the German Cancer Research Center in Heidelberg, Germany. His research focuses on understanding the complex interactions between humans and the bacteria that reside in their gut and how these interactions shape human health and disease.

EPISODE LINKS:
Show notes and transcript:

PODCAST INFO:

Chapters
00:00:00 - Introduction
00:02:14 - Circadian rhythm of the microbiome
00:12:53 - Lessons from Hunter-gatherers
00:20:20 - Nurturing the microbiome in children
00:30:52 - Triglycerides and cholesterol
00:34:34 - Saturated fat
00:36:01 - Effect of artificial sweeteners on the microbiome
00:51:46 - What causes recurrent obesity
00:53:53 - Impact of caloric restriction
00:55:02 - Intestinal permeability (gut leakiness)
01:15:30 - Bacteriophage therapy and precision probiotics
01:30:20 - Bacterial role in TMAO risk
01:36:09 - Weight gain from smoking cessation
01:37:29 - Tips for diet personalization

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PODCAST:

#microbiome #weightloss

[xDomGrox]

Am I the only one who thinks there is very little practical information? Its all very technical and he goes deep into some of the mechanisms how things work. Its "nice to know stuff". But he didn't really give any real life advice on what foods tend to be good for most people or at what times it is good for most people to eat. He even says fiber is good in general, but not all fiber, is equal without even mentioning which foods tend to have "good" / "bad" fiber.

[James-mkjp]

This guy is the kind of scientist I love. Tries very hard to be aware of assumptions and biases, not jump to conclusions, and asks lots of valuable questions in his work. Keep it up!

[meekachuichooseyou]

I love your podcasts so much. I do pretty consistent fasting routines and find it really helps my gut. I’ve tried carnivore a few months when I was having some health issues and that restriction definitely had positive effects and I slowly incorporated certain veggies/ fruits back. I do find if I eat similar foods consistently my body functions very well compared to what It used to. Cutting back drastically on processed foods definitely helps as well. If it wasn’t for all your information you are willing to put out I just really don’t know how down hill my body would have went. You are so much appreciated! 🙏🏼

[pcaul]

Dr Will Bulsiewicz would be a great guest, he's one of the leading gastroenterologists in the US and an expert on the microbiome.

[kenycharles]

Thank you for this presentation.

If I had ever heard anywhere before that the gut microbiome had a circadian rythm, well, I had forgotten. And that's only one of the highlighted points in this video.
I don't know how many languages Dr. Eran Elinav can speak, but I am glad English is a language he is fluent in.

[davidlohrentz]

Regarding the study cited at 1:10 on "Personalized Gut Mucosal Colonization ..." that showed that about half of the individuals responded to probiotics, while the other half did not, I am curious how long they followed this, and might it have ultimately changed if extended far enough, or is it the case that some individuals will just never respond to certain probiotics? The Sonnenburgs talked about it taking years to shift the microbiome, and that has been my N of 1 experience. Two years ago, I had to avoid high fiber foods such as burdock root; after banging away with higher and higher fiber and daily intake of sourkraut, kefit, natto etc, now I can stomach about anything. It was a very gradual change, that took many months.

[iglapsu]

You all are providing a great service to the public writ large suffering from these types of maladies! Thank you!

[carpediemjonah]

John Kennedy once said, "The greater our knowledge increases, the greater our ignorance unfolds." What a great challenge this microbiome research still faces. Outstanding interview.

[earthangel]

Great show! Here's a question: If we eat food we grow in the back yard, would our gut microbes welcome their "neighbors" which come from the same physical area where the host lives? Is there data on the gut biomes of farmers, gardners etc. who eat the food they produce themselves?

[Lauren-vdqe]

interesting message. I notice your face is very shiny! did u just put like some coconut oil on it? for future filming you might want to take all oil off it then dust it with translucent powder that will eliminate the shine factor. thats what tv studios do.

[ecgplyx]

I was disappointed in the fact that he didn’t talk about the types of things we can eat to help our gut microbiome. He briefly stated sleep and losing weight helps, and suggested fermented foods help; however, he mostly talked about medicine opposed to natural remedies we can tackle as well. He comes off as a big pharma type guy.

[gefginn]

This field is Exploding in awareness and understanding of impact on our health. I appreciate all I can learn concerning this. Thank you so much for sharing this information here. Blessings. 😇🥰

[askingwhy]

This kind of hype-free research is solid gold. Like everyone else, I want an immediate solution, but that's not how the world works. Getting insight into the long, complex process is worth much more than empty promises.

[beares]

There is one point that would be interesting to deepen and that is about the circadian rhythm.
It appears that melatonin has an impact on the microbiome, which would make exposure to sunlight even more important, a habit we have lost with the modern lifestyle.

[NorCalif-pkkq]

Absolutely EXCELLENT information. Thank you!!

[Crystallightclarity]

I'm so happy my children have a pediatrician who doesn't over prescribe antibiotics. I wasn't afforded the same caution from doctors as a toddler/child.

[jimbeaver]

why is he talking about studies with saccharin when it has long been proven bad and is not used anymore, at least by Keto folk - I want to know the effect of erithritol, allulose, etc, the new generation of sweeteners

[ThomasAT]

Fantastic interview, constant attempts to bring in nuance and objectivity which I very much appreciate. Thanks!

Project CGM in combination with food testing is planned for this year, can't wait.

Love and strength,
Thomas

[godhash]

Love your format, very informative! I really appreciate, that you put descriptions whenever you speak about a compound or other, it's very easy to understand. Thanks!

[foodheal]

This is hugely informative and quite interesting. I am fascinated by the gut microbiome and on this podcast, I was well served. Thank you for your beautiful work.