Antipsychotic Medications Demystified: A Comprehensive Guide to Types, Clinical Use & Side Effects

In this YouTube video, Dr Sanil Rege discusses the neurobiology and psychopharmacology of antipsychotic medication. Dr Rege explains that antipsychotics are not just used to treat psychotic symptoms but also have additional properties such as antidepressant and anti-anxiety effects. The video covers different ways that antipsychotics can be prescribed, including long-acting depot injections, and the importance of maintaining a steady-state medication level for patients. The presenter also explains the various symptoms associated with psychosis and how different pathways in the brain are affected by antipsychotics. The goal of treatment is to reduce positive symptoms while maintaining mood and cognition, and preventing the side effects of increased prolactin levels.

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Timestamps:
00:00 Intro
1:47 What are antipsychotics?
2:34 Antipsychotic medication uses
3:31 Dopamine pathways
6:12 Antipsychotic categories
7:53 Antipsychotic medications in Australia
8:42 Antipsychotic agents without dopamine blockade
9:48 How do antipsychotics work?
10:11 The role of the 5HT2A receptor
10:28 Partial agonists & the goldilocks effect
11:50 Antipsychotic types and their relation to symptoms
12:19 Possible side effects of antipsychotics
13:09 Tolerability antipsychotics
14:36 Managing side effects of antipsychotics

#NeurobiologyOfAntipsychotics
#PsychopharmacologyExplained
#AntipsychoticsBeyondPsychosis
#LongActingDepotInjections
#SteadyStateMedication
#PathwaysInBrain
#ReducingPositiveSymptoms
#MaintainingMoodAndCognition
#ProlactinSideEffects
#AntidepressantEffectsOfAntipsychotics
#AntiAnxietyEffectsOfAntipsychotics

[kevinherron]

I would fly around the world to be treated by doc Sanil

[patrickm]

I’m experiencing chronic side effects from antipsychotics. Chronic aches and pains, chronic fatigue, mental anguish, depression, insomnia, vomiting. Fully disabled from these medications struggling to shower, brush teeth, change clothes, cook, do housework. Help my psychiatrist won’t let me stop taking them. Beware!

[beverlyteh]

Well. I’m here for a positive comment Sanil! Such a succinct video which I will point my medical students and juniors towards. Bravo!

[katmahbub]

so well explained, integrating neurophysiology, clinical and pharmocology.

[am]

Amazing video. I have 2nd year exams in few days and ur vid is extremely helpful for neurobiology and pharmacology too!

[UltimateEnd]

Back in 2011, I got treated with very heavy risperidone and then ziprasidone (Geodon) and I experienced extremely bad restless leg syndrome like I was about to call 911 for an ambulance. However, I was able to play a game (Castlevania:Harmony of Despair) until my symptoms subsided. Risperidone was much worse for my restless leg syndrome.

[RajSharma-gi]

These short videos will facilitate to de-stigmatize the views of mental health and patient suffering held by the public and the medical/psychiatric professionals.

[shieldmetal]

Is there a relationship between getting psychosis because of trying drugs. And if there is...are those people given antisychosis medicine

[sorianasor]

why sometimes combination clozapin with fluvoxamin?

[hopelesslyhopeful]

Thank you very much for this video. I have a question: atypicals that are not partial agonists, but only have D2 e 5HT2A, do create a situation where the combined effect brings (in the pathways that are not the positive symptoms related ones) a level of dopamine that is the "normal" one you would have without the med, or do they create a higher level of dopamine in those "areas"?

Asking because i am curious about the antidepressant proprierties. Are they caused by the fact that low dosage of atypical antypsychotics can cause a slightly higher level of dopaminen in the area related to affective symptoms?

[jogigeorge]

Is there any relationship between Primary aldosteronism and bipolar disorder

[mobillegenuiya]

Sir could i ask for the link of hyperbolic tapering of antipsychotic

[danielfaherty]

Hi Doctor, I am taking Olanzapine mainly for negative symptoms of schizophrenia. I don't have any positive symptoms. I like Olanzapine but I sleep for 12 hours a day. That's hard for me to deal with. Can you recommend an antipsychotic that I would sleep 8 hours instead of 12.

[DennisBolanos]

When I was 8 years old, I was prescribed Risperdal 1 mg/d for autism, along with Dexedrine Spansule 40 mg/d. To this day, I’m intrigued as to why my psychiatrist recommended this combination. 🤷

[neetusharma]

Is taking Aripiprazole 2.5 mg daily increases weight gain and diabetes. Plz reply.

[Nick-iuks]

I saw a tinnitus specialist (Professor Dirk De Ridder) who prescribed 0.5mg flupentixol to block D1 and take focus off tinnitus + 2mg Aripiprazole. He said the flupentixol should be taken with 0.5mg of Clonazepam to reduce chances of tardive dyskinesia. Is the risk high at this dosage? Is the Aripiprazole added to counteract the flupentixol?

[naseermushtaq]

Age 25 male Plz tell me? Currently on lexapro 10mg oleanz 5mg does olanzapine cause diabetes em taking this medicine from almost 7 months em confused whether to continue med or not plz help me out? Bcz of fear of diabetes

[subhashnc]

Amisulpride causing sexual dysfunction..i switched to aripiprasol its cause akathesia...how i get my sex drive back

[RichardHead-swdm]

What can a person do if they are being given this type of drug sneakily in other medications PLEASE HELP

[mobillegenuiya]

Sir does this drug cause vivid dream. Because i get vivid dream while on this med and i feel like im barely sleeping no matter how long i sleep please sir help me out my psychiatry have no idea. Im so tired of this.