Assessing the benefits of HIPEC in GI cancers

Deepa Magge, MD, FACS, Vanderbilt-Ingram Cancer Center, Nashville, TN, discusses whether there is still a role for hyperthermic intraperitoneal chemotherapy (HIPEC) in treating gastrointestinal cancers with the presence of cytoreductive surgery. The Phase III PRODIGE trial (NCT00769405) concluded that addition of HIPEC to cytoreductive surgery did not improve outcomes in colorectal peritoneal metastases. However, further research is needed, where mitomycin C was used in the trial and oxaliplatin is the standard chemotherapy of choice for HIPEC in America. This interview took place virtually at the 2022 Great Debates & Updates in Gastrointestinal Malignancies Congress.

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