NU-9 and the Importance of Upper Motor Neuron Health in ALS

Our speaker Dr. Ozdinler, Associate Professor of Neurology at Northwestern University will discuss the NU-9 and the importance of Upper Motor Neuron Health in ALS.

Dr. Ozdinler is an Associate Professor of Neurology at Northwestern University, Feinberg School of Medicine. She is also a faculty member at the Les Turner ALS Center, the Mesulam Cognitive Neurology and Alzheimer's Disease Center and the Robert H. Lurie Comprehensive Cancer Center. The Ozdinler Lab is interested in understanding the molecular and cellular basis of neuronal vulnerability that is observed in distinct neuron populations in different diseases. We focus our attention to the upper motor neurons that die in ALS, HSP and PLS. However, the lab has a broad interest in the common cellular mechanisms that lead to neuronal degeneration. They have generated and characterized the first reporter line for upper motor neurons and developed a novel drug discovery/verification platform that incorporates improved upper motor neuron health as a readout. Interestingly, even for the diseases that have been characterized by the loss of upper motor neurons, their health has never been considered for any of the preclinical assays. In addition to being a scientist, P. Hande is a painter, a writer, an international press member, a mother and an advocate for women, science and education. She invented a new form of painting, the OzdinART, received TradeMark for it as it allows 3D painting on Canvas with less than 1 micrometer resolution of colors, where colors retain their identity without blending in, but mixing together to generate a motion of connectedness. P. Hande's husband Derya Ozyurt and P. Hande started Art Loves Science Foundation, a non-profit which aims to promote science education for students and to initiate funding for the very early stages of innovative and collaborative ideas.

[nilookarimi]

This is a huge hope for people with als. My mom has als and as I read about this discovery I was happy in tears and she was just so hopeful so she can hang on and fight to live! Thank you. Thank you. I hope this is gonna work and help thousands of hopless people around the world like us from iran. U people are the answers of my mom's prayers every night❤️❤️❤️❤️

[nilookarimi]

Als patients have nothing to lose to have much time! They don't care about toxicity! Sometimes they just wanna die sooner so toxicity is nothing they care about! They just wanna get better sooner or die sooner! I wish nu9 get available all over the world as soon as possible🙏🙏🙏🙏🙏

[patriciaperry]

Thank you doctor for working so hard. My client got ALS at 27 and has been in bed for 13 years 100% paralysed, he is now 40, he is optimistic and wants to live. A reversal of any part of his body will completely change his life.

[ssmania]

IM really hoping this gets approved quick!!!

[fourshore]

Loved this. Thank you! I really hope NU-9 proves to be as good in humans as in mice.

[metabalance]

Does have NU-9 also any antiretroviral activity ? Any anti-transposome activity? Any anti-viral-RNA-polymerase? What is the difference betwen the coloid-aurum solutions and NU-9 ?

[julietadienstmann]

Hi! I'm from Brazil looking for NU-9 information. I've been looking for Northwestern and Dr. Ozdinler to know how to enroll to be part of the clinical tests when it starts. Please, anyone here that can help me to find this information?

[qvnihdm]

People never seem to give thanks to all the mice and animals who sacrificed their lives and probably suffered and were in fear and torment because of human research. 😥God bless all those living things!!! 💕

[fourshore]

shouldnt everyone be taking NU-9 as a preventative measure?

[Cangurul]

What means this practically for an ALS patient? Because I suppose that i can only heal the neurons that are not dead, that means it can stop the evolution of the disease but clinically the patients won't see a substantial improvement / regain of their muscle functions or??? Thank you!

[louvoodoo]

In canines Degenerative Myelopathy is similar to ALS. My dog had fighting this disease for a year. She may only have a few weeks of mobility left. May I please get her on NU-9?

[felipetartarotti]

Hi Guys, any news about Nu9 ? Thank you

[penguinshoes]

The C-boutons enlarge earlier in ALS than anything you addressed, long before any symptoms, at onset of excitotoxicity. Your SOD1 mutant comment at 11:20 is off base. There is a delrin-1 binding region that can be corrected. I am going to stop ALS. Your main valid comment is that it is unrealistic to believe a single drug (or substance) will address every aberrant function. You are limiting options to drugs, and the parallel approach is still flawed. I do like your presentation.

[lanphuongnguyen]

the sound is not good I am quite disappointed