Tetracycline: The Rise of Pfizer

The history of tetracyclines, including the rise of Lederle-Cyanamid's Aureomycin and Pfizer's Terramycin.

☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️

🔗 L I N K S 🔗

🔑 P A T R O N S 🔑
Joanne K
Sal F.
Jim Clay Jr
Ansel K
Brandon K
Pranav M
Paul
Brendan P
Dane M
Kristoffer R
Jakub V
Joe B
Karly N
Mindi F
Drake W
Kathy K
Mike W
Hyeon-Seo
Jacob S.
Robin B
Robb W
Sarah B
Dontae W
Karen S
Michael R
Brian H
Jonathan G
Brian T
Waffles the Dog
Thelma S
Silverstar
Brian B
Michael G
Zoe C

SOURCES
The Miracle Cure by William Rosen

IMAGES
Wellcome polio vaccine. Wellcome Collection. Source: Wellcome Collection.
View of Sanborn Field from the adjacent Bond Life Sciences Center on the University of Missouri campus by Lwtwb8 (CC BY-SA 3.0)
Rickettsia typhi by David H. Walker (UTMB), George Weinstock (BCM-HGSC)
Tetracycline HCl substance by Rillke Creative Commons Attribution-Share Alike 3.0 Unported
Arthur M Sackler in his office. Smithsonian's Freer and Sackler Galleries. CC BY-SA 2.0 DEED

VIDEOS

⌛T I M E S T A M P S ⌛
0:00 Intro
0:46 Part 1: Pay Dirt
6:52 Part 2: From the Earth
12:20 The Lawsuit
14:52 Part 3: New Generations of Tetracyclines

💻 C O N T A C T 💻
If you’d like to sponsor a video or have other business inquiries:

[PatKellyTeaches]

If you want to support my work, join my community of medical history nerds over on Patreon, . You can join at as little as $2/mo. I appreciate ya. www.patreon.com/corporis

[lindaacevedo]

I was born in 1949 and developed a soft tissue infection that initially responded to Penicillin. Eventually, my body developed resistance to Penicillin due to the recurrent infection. I became septic and the brand-new drug Acromycine was used on me, saving my life. This is from my family's oral history.

[beaglebeard]

Apparently YouTube and antibiotic research have something in common - needing to sift through endless piles of dirt in order to find something great. So glad I stumbled across your channel a little while back, you are my aureomycin

[outrageous-alex]

Excited for the next one! I worked in a Feed manufacturer in PA for a few years, they had a whole presentation on how they used to use antibiotics because it causes chickens to grow faster and healthier/bigger but now they can't so they use vitamins to try and replicate the effect.

[RyJones]

This explains so much. My grandfather, Lawrence R Jones, worked for CSC in Terre Haute and got tons of patents for CSC. He didn't get a patent, but a nice plaque, for figuring out how to turn what became neosporin from something that had to be prepped into a stable ointment you can sell.

[dynkus]

Pharmacist here. Med Chem was my favorite part of pharmacy school, and I love hearing about the history of how our drugs were developed. Keep up the good work!

[Citizen-]

Yella Pragada Subbarao was a major yet unknown figure in the development of tetracycline.
Duggers succeded in his attempts after valuable insights and generous sharing of findings from SUbbarao.
Yet even today subbarao remains unknown to most.
Subbarao was the director of research at lederle.
Most of his important works were destroyed by Fiske who also forced Subbarao into giving up credit for the isolation of Folic acid.

[chasemcclure]

This was a great video. I'm a Stevens-Johnson Syndrome survivor as a child caused by an reaction to "Tetracycline" and I've always known I was allergic to it. But really had no idea what it was.

[jerdog]

I was born (my kids would say found) in 1958. I had ear infections. I had those little tubes placed in my ears. I remember that summer vividly as our family had put a pool in, and I got to watch everyone ELSE go swimming in the new pool. Traumatic for a little guy.
Anyway I was put on a new wonder drug antibiotic. Teramycin. It turned my teeth yellow. At age 5 my baby teeth looked like a 5 pack a day smoker and a coffee drinker by the gallons. My adult teeth were also discolored. So I have some personal issues with Teramicin and Pfizer. Has to do with voodoo dolls.

[symmetria]

Great video as always and I’m excited to see the next one! Recently I’ve been seeing a bunch of ads for chicken raised with zero antibiotics (Perdue, I think?) which have led to me realizing that giving antibiotics to chickens that aren’t even necessarily sick was the norm, and this made some serious antibiotic resistance alarm bells go off in my head, so it’ll be interesting to hear more about how farming practices contribute and also just learn more about the topic in general!

[dyslexicfomo]

I worked a summer job 1974 at Cyanamid,

Lederle Lane, Gosport UK analysing when to harvest the tetracycline from the fermenter. It was quite a fun job using a colorimeter. The place shut down some time ago. Now they wonder why there is a worldwide tetracycline shortage.

[hedgehog]

It's really interesting how all of these huge pharmaceutical companies started off mostly as small dye producers and then the coincidence of gram dying brought them all into medicine where they'd go on to become some of the biggest companies in the world.

[bread]

As a biology student, you videos are both informative and really interesting to watch in between my classes. Thank you for the effort you put in this videos ❤🙏

[elnombre]

Glad to see RBW getting mentioned, truly a legendary organic chemist.

[zipsey]

Babe! Pat Kelly dropped his tetracycline video!!!! Wake up!

[Anonymous-mfj]

Pat, you're criminally undersubscribed. I've been bingeing every video for weeks now, each one is so interesting. My favourite part? It has to be how respectful you are to the viewers time you touch on other video topics and move on without repeating all the extra stuff to push out the video length.

Thanks again, excellent information.

[scpatlnow]

I really love these videos! I just took my last dose of Doxycycline HCL for an infection. It's nice to know where it came from. I also remember when Erythromycin was a literal go-to for most bacterial upper respiratory infections

[therakshasan]

As a child I had Rheumatic fever . I was given Aureomycin . It saved my life, but stained my teeth yellow for life .

[davidsault]

I'm seventy years old and can follow in detail all of this only because I'm a Boomer who paid attention during the most information saturated time in human history. This is a great video. Thanks.

[jannmikoingelrabagogamingc]

As a Filipino BS Pharmacy student, I am actually quite surprised that Erythromycin was discovered by a Filipino scientist; searched it up and found that his name is Abelardo B. Aguilar. Although it was mentioned before that there was a Filipino scientist who discovered an antibacterial drug, I never knew that it was Erythromycin all along anyway hehe.