Glycogen metabolism

What is glycogen metabolism? Glycogen is basically an enormous molecule or polymer, that’s made up of glucose molecules linked together by glycosidic bonds. After a meal, high insulin levels promote glycogen synthesis, whereas during fasting, high glucagon and epinephrine levels promote glycogen break down. Glycogen is considered the major form of glucose storage in the body.




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[m.eminkokturk]

Wow, you summarized every and each detail just in 10 minutes. I really liked the animations and how to the point this video is.

[bhavleen]

Glucose and Glycogen
Glucose is a 6-carbon molecule used to make energy in the form of ATP
Excess glucose is stored in skeletal muscle cells and liver cells as glycogen
Glycogen is a large, branched molecule made up of glucose molecules linked by glycosidic bonds

Glycogen Synthesis
Four main steps in glycogen synthesis:
Attaching UDP molecule to glucose
Attaching glucose part of UDP-glucose to glycogen primer
Adding more glucose molecules to the primer
Adding branches to the glycogen molecule
Enzymes involved: phosphoglucomutase, UDP-glucose pyrophosphorylase, glycogen synthase, and glycogenin

Glycogen Breakdown
Glycogen breakdown occurs in response to low blood glucose levels
Enzymes involved: glycogen phosphorylase, debranching enzyme, and phosphoglucomutase
Breakdown occurs in liver and skeletal muscle cells, with different enzymes used in each tissue

Regulation of Glycogen Metabolism
Two pancreatic hormones regulate glycogen metabolism: insulin and glucagon
Insulin promotes glycogen synthesis and inhibits glycogen breakdown
Glucagon promotes glycogen breakdown and inhibits glycogen synthesis
Regulation occurs through phosphorylation and dephosphorylation of enzymes involved in glycogen synthesis and breakdown

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[chatzzz]

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[santicruz]

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[abdallahdawod]

2:49 the right Pyrophosphorylase cuts one phosphate from glucose-1-phosphate and the second frome UTP ☺️

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[gyoseph]

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