Making stem cells with chemicals.

When people think of cellular reprogramming, converting a differentiated cell into a stem cell, they often refer to the overexpression of Yamanaka factors [Oct4, Klf4, Sox2 & c-Myc]. Rightly so. But what if i told you that stem cells could be induced with just chemicals. Well you would reply "show me the data". So, let's take a look at this recent Nature paper that showed how combinations of small molecules/chemicals converted human differentiated cells to stem cells.

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TIMESTAMPS:
Reprogramming with small molecules - 00:00
What this tells us - 04:45
Outlook - 08:35

References:

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

[TheSheekeyScienceShow]

There's a rumour that if you subscribe to my channel cellular reprogramming efficiency will increase.

[mmjvtnl]

Really appreciate your analysis as well as your sense of humor. You really have a way of making my joy of learning even more fun!

[pepenavarro]

Great video. Anyone can understand this complex scientific article with your analysis. Thanks

[PowerhouseCell]

This was very well explained, amazing video as always!

[rigaleb]

This is... groundbreaking. We are really enetering a new era. Give it at top 20 years and some few hundred million dollars and we'll see it in vivo working just fine and dandy.

[stonebridge]

Yay Cambridge! Go plasticity go! Although they did forget eye of newt and liquid frankenstinium in the potions. Please continue your rhetorical musings, Dr. Sheekey. I'm compiling them for the faithful and therein we shall find the *pattern* of divination.

[BartdeBoisblanc]

Great explanation on this subject Sheekey. I started thinking with all these ways of triggering regeneration you would think cells in humans and animals have a mechanism that does this automatically now. This question might have been answer perhaps on the subject of diet, exercise or sleep in some of your other videos but I thought I would ask anyway.

[tekir]

Thank u so much for this video. Understandable, basic and funny!

[tyanite]

Apologies for asking an off topic question. I imagine the answer would be yes, but I wanted to be sure to ask and not rest only on my assumptions : Does extended fasting clear senescent cells? Thanks for all you do!

[SeanKula]

What's the off Target effects/efficiency of this molecule?

[talokeen]

CAN I MAKE HOME RESEARCH USING YAMANAKA FACTOR

[DomremySurMeuse]

In vivo, would we really want to go all the way to pluripotent? That would be very risky, I would think. According to David Sinclair, et al, we only want an in vivo *partial* reprogramming to re-set the epigenetic program. So does this mean that anti-inflammatory supplements (like curcumin and/or senolytics) might aid in partial de-differentiation?

[wangshuo]

To supplement, in early 2023, the new version of small molecules has successfully increased reprogramming efficiency by dozens of times. The highest reprogramming efficiency has now reached 30%! Moreover, the time has been shortened to 16 days, and serum has been removed, now only chemical small molecules are used. They have developed a reprogramming kit, and now reprogramming can be done in the simplest way.

[stefanallard]

there is a drug thats used before stem cells iv, a injection. that triggers stem cells from bone marrow before harvesting. i wounder when that will be sold in powder form. never heard anyone talk about it before

[johnmahoney]

Please be so kind as to comment on: "Mitchell E, Spencer Chapman M, Williams N, Dawson KJ, Mende N, Calderbank EF, Jung H, Mitchell T, Coorens TH, Spencer DH, Machado H. Clonal dynamics of haematopoiesis across the human lifespan. Nature. 2022 Jun 1:1-8." Thank you.

[user_a]

So using a load of complicated multi stage chemicals we get 2% conversion rate to some un-defined end point? - That's all I got from this video.

[abdullahhazari]

What shocked me is fact that your video is only one I found in YouTube describing such breakthrough in human history. Regarding that there is no intrust on such fundamental and important issues means that western civilization must lose competition against China's civilization. Coming YouTube i asa milions of stup videos ....

[movementcontact]

I'd like one HUGE injection in my prefrontal cortex area, please... ✌️🥴