Extracellular K+: spatially varied Gaussian curvature, input to flat area

Input stimulus to an area of zero curvature on a tissue slice with randomly generated surface properties and spatially varied Gaussian curvature.

The K+ and vasoconstrictive wave travels outwards from the input stimulus. The wave breaks when it reaches areas of positive curvature producing multiple wave segments which either grow (possibly forming loose spirals) or cease depending on the curvature and wavesize.

Left: extracellular K+ concentration [mM]
Right: Gaussian curvature, percentage change in blood flow