FAME 3 trial: FFR-guided PCI vs CABG

Better outcomes have been demonstrated with coronary artery bypass grafting (CABG) than with percutaneous coronary intervention (PCI) in three-vessel coronary artery disease (CAD). However, the PCIs performed in these studies were guided by angiography, not fractional flow reserve (FFR) measurements.

In the FAME3 trial investigators aimed to conduct a noninferiority trial to compare FFR-guided PCI to CABG.