Immunology Map V - Cell Mediated Immunity

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[armandohasudungan]

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[armandohasudungan]

Hey Aristo,
Sorry if its a bit confusing.
1) Basically T cells coming from the thymus are naive CD4+ or Naive CD8 T cells. THey are not Th1 or Th2 or CTL YET. Once they arrive at the spleen or lymph organ somewhere, they can be activated to T helper cells or t killer cells.
Naive CD4 will always become some form of T helper, cause it has a CD4 receptor.
CD8 cell when activated will become a killer cell or memory.
CD4 and CD8 is just used to say what type of receptor it has.

[nerdchick]

Antigen is first recognized by TCR then CD8 checks for the presence of MHC. T cells can only be activated when APC presents the antigen combined with MHC II complex only.Once the presence of antigen and MHC is checked, signals are sent to the T-cell nucleus. But.But that is not enough to activate the T cell. Hence CD28 and B7 provided the necessary " CO-Stimulation". Gene produces IL-2, which acts on T cell itself.IL-2 has autocrine activity.This stimulates GENE 2 to produce IL-2 receptors.IL-2 receptors is transported to the cell membrane. IL-2 protein fits into IL-2 receptors  and this stimulates genes related to cell cycle to start Mitosis.

[aamd]

Thank u very much, very very much .

Your channel is one of the best channels i have subscribed.

Carry on bro

[lovekibainuzuka]

clear, succinct, highly understandable, highly related

[thekhmer]

I am so grateful for your animated lectures, Armando...

[AristoKan]

After a lot of thinking i came up with the same conclusion and then i checked the comment of yours.
Thanks a lot for replying!!
I will share your videos with my colleagues.
P.S I've always been using schemata in my studying so your way is really helpful and similar to mine.
Greetings from a Greek

[armandohasudungan]

2) T reg, etc, of what I know are not formed in the thymus, they can be I guess, if they are presented with an antigen in the thymus. But usually T reg and Th17, etc are activated in lymph nodes. Cause this is where dedritic cell usually bring the antigen to present to the Naive T cells.
And from there the T reg can activate the B cells.

[kay]

Wonderful.
I agree with a former comment that the patho texts are not written for being able to critically think. Way too much information.
These videos are short, take you thru the processes, and really cement the information.
Amazing. I have subscribed and will watch them all.
I support your work.
What a great tool for those who really want to learn and apply the information.

Kae

[eddieanton]

Excellent video sir, much appreciation for it. One thing that stuck out to me however is @ 7:00 in regards to dendritic cell presenting Ag protein via MHC1. This APC uses MHC2.

[bugMASTER]

Hey there, Awesome videos! I have an exam today and this helps me to repeat everything!

By the way: for the CD4+ Tcell differentiation i think you mean TGFbeta (Transforming growth factor beta) instead of "IGFb"

-> Differentiation of Th17 and Treg cells, In B cells inhibition of proliferation and IgA production,
In macrophages inhibition of activation and stimulation of angiogenic factors
And in Fibroblasts increased collagen synthesis.

Keep up the vids ! :)

[Kergilliack]

Thankyou so much this is incredibly helpful, i'm so glad you include the cytokines as this really improves my understanding when i have the full picture :)

[pabloo]

Thank You so much for your videos!! I have an exam tomorrow and you have helped my understanding greatly. Hopefully i pass. 

[raechen]

Your detailed animations are really helpful, thanks man!

[MimicIsaac]

Hey! This is such a useful resource. May I suggest just taking pictures and then stitching them into a "panaroma". Can be done on photoshop or other free software online. Some android/ios apps on the phones can do this for free as well.

[Placebo]

immunology final tomorrow, thank you for this!

[elnazm]

Great explanation. I just love your videos. which video includes the Activation of B cells ??

[ashn]

B cell requires two signals to become activated:
1) Antigen binding
2) Stimulation by T lymphocyte
So, when mature, naïve B cell enters lymph node, it is exposed to antigen and then stimulated by T helper cell before it moves into germinal center to proliferate and differentiate?
If so, where did the antigen come from, i.e how was it presented? By a dendritic cell? Was it free floating in the blood?

[Madiha]

You made easy medical studies through your videos😊

[ranahijawi]

Your work is amazing. Thank you so much.