Caution with Codeine

Codeine is metabolized in the liver into Morphine by the CYP enzyme. A small portion of the population are characterized as ultra-rapid metabolizers and therefore they experience high concentrations of morphine which can lead to respiratory depression and death. Bottom line - Use caution with codeine!

[bluest]

This is fantastic!! Thank you. Hoping my metabolism is high.

[AzraelisHorny]

ive barely taken drugs in my life but just had my first surgery and got this prescribed and its fooking noice thanks for the info i like knowing what i put in my body

[yvonnejohnson]

Omg I wish I’d seem this three months ago. I’ve been given Dihydrocodiene for three months for a herniated disc bulge. I have lots of other conditions, including ME, Fibromyalgia, Pots, Sjogrens Syndrome and Atrial Fibulation etc and I don’t tolerate many medications. My GP insisted that I needed this medication, I’ll be contacting my GP tomorrow that’s for sure. I’m in the UK.

[dmtelfireland]

A known dose of codeine is an unknown dose of morphine.

[rjfisher]

Very interesting and informative information. Your communication skills are outstanding. Very concise. Thank you for an outstanding video.

[steveevansphotography]

My doctor gave me oramorph morphine, zormorph morphine and cocodomol so they wonder why I was out of my head

[antoineleedolliole]

Brother, I cracked up when you drew that line and explained so professionally how some of us have that 34% chance to get super f#$$%d up on accident from persciptions measured without accounting for the demographic.

This video is awesome!

[alisaeed-htsq]

Just took 2 co-cordamal tabs for toothache & earache. Starting to feel the horrific pain subside.

[nickydaviesnsdpharms]

Interesting subject: I'm a recreational drug user but was a heroin addict until 2004, and i only found this out due to the heavy reading I always did and still do on pharmacology. It's the Cytochrome P450 super family of liver enzymes but particularly the subset CYP 2D6 isn't it, that converts Codeine into the more active form Morphine, so basically a pro-drug. As I understand it Codeine is Methyl Morphine, Morphine with a CH3 functional group on its chemical structure. Also, Codeine isn't biologically active in of itself.
Another related fascinating topic you may have covered in another video s the consumption of grapefruit juice alongside certain medicines, this causes an interaction because of another CYP P450 enzyme CYP3A4 raising the blood levels of many medications extensively,

[bubblezovlove]

I wish that was the least of my problems. I only take Codine as a way to manage Fentanyl side effects from chronic spinal. 🙁

[khelanivisions]

This probably the reason lil keed passed away

[ValentinaKajcinovska]

They must take alot to cause respiratory depression and or even death!

[Dips-gx]

Im on codeine after septoplasty surgery. Just makes me drowsy and numbs pain

[donskii-sxhw]

Can I be tested to see if I'm a high metaboliser?

[MrAxendersp]

Cool..so how do we filtert out morphine from the pee or whatever...

[giftlungu]

Thank you Dr. I really thought you were gonna bring up the CYP450 isoenzymes, especially, CYP2D6
for Codeine, anyway thank you for your time sir.

[Haxxl]

Im watching this while being on codeine

[nostromo]

My doctor gave me 30mg tablets for pain. It makes me very itchy especially around my face. Its the weekend. Should I go to Emergency? I am not in severe pain now.

[fridasophia]

Just took 150mg welp guess I'll die

[rhitalex]

thanks for this scary video! Well !! wasupp?? myself codeine addicted person! like hell!! and i m about to be dead anytime for sure! 🥲