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WHAT IS THE ENDOCANNABINOID SYSTEM (ECS)?
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The endocannabinoid system is a signalling system found in nearly every species of mammal. It consists of two cannabinoid receptors, CB1 and CB2, and the fatty acids anandamide (AEA) and 2-AG that bind to them, in addition to the enzymes that synthesize and degrade them. The ECS is notable because, unlike most signalling systems, it facilitates retrograde transmission, or post-to-presynaptic transduction.
Most neurotransmission is anterograde, or forward, traveling in a pre-to-postsynaptic direction from axon to dendrite. When a postsynaptic dendrite receives a signal, it releases either AEA or 2-AG and they travel "backwards" to the axon where they complete either a positive or negative feedback circuit by increasing or decreasing the firing potential of the presynaptic neuron. This is the fundamental purpose of the ECS, and this essential model is present in nearly every cell in the mammalian body in some form.
This is why the ECS is involved in everything from memory consolidation to the release of hormones; it allows the brain to communicate with itself to maintain a balance by either increasing or decreasing activity after every single transmission.
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About What Is CBD:
We are an unbiased informational blog focused on providing highly accurate information brought from doctors, lawyers, healthcare and pharmaceutical professionals, cannabis industry influencers, and more. Our goal is to be the premier source of truth and accuracy concerning anything related to CBD or medical Cannabis, coming straight to the reader from the minds of the highly qualified professionals mentioned above.
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Get More What Is CBD:
The endocannabinoid system is a signalling system found in nearly every species of mammal. It consists of two cannabinoid receptors, CB1 and CB2, and the fatty acids anandamide (AEA) and 2-AG that bind to them, in addition to the enzymes that synthesize and degrade them. The ECS is notable because, unlike most signalling systems, it facilitates retrograde transmission, or post-to-presynaptic transduction.
Most neurotransmission is anterograde, or forward, traveling in a pre-to-postsynaptic direction from axon to dendrite. When a postsynaptic dendrite receives a signal, it releases either AEA or 2-AG and they travel "backwards" to the axon where they complete either a positive or negative feedback circuit by increasing or decreasing the firing potential of the presynaptic neuron. This is the fundamental purpose of the ECS, and this essential model is present in nearly every cell in the mammalian body in some form.
This is why the ECS is involved in everything from memory consolidation to the release of hormones; it allows the brain to communicate with itself to maintain a balance by either increasing or decreasing activity after every single transmission.
────────────────────────────────────
Check out our other videos!
────────────────────────────────────
About What Is CBD:
We are an unbiased informational blog focused on providing highly accurate information brought from doctors, lawyers, healthcare and pharmaceutical professionals, cannabis industry influencers, and more. Our goal is to be the premier source of truth and accuracy concerning anything related to CBD or medical Cannabis, coming straight to the reader from the minds of the highly qualified professionals mentioned above.
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Get More What Is CBD:
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