Deconstructing The Epigenetic Methylation ClocK

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did any of the modules correspond to U-shaped curves in the paper "Epigenetic aging waves: Artificial intelligence detects clustering of switch points in DNA methylation rate in defined sex-dependent age periods"?

InquilineKea
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Causal Epigenetic Age Uncouples Damage and Adaptation - which modules do protective ones from this fit in?

InquilineKea
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18:31 is the MOST important slide. Why do more interesting sites lose methylation with age? Only pink and navy gain methylation with age (they start off with low DNAm so it could be drift). Methyl donors probably good

InquilineKea
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Is light blue the only module that gains CpG with age? Pink and purple cpgi

InquilineKea
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lol yellow-green module in levine's paper..

HM HOW SPARSE ARE THE CPG MODIFICATION SITES IN THE AFFECTED CPG'S? SPARSE CpG sites change WAY more with aging (VERY recent paper ruxandra tweeted)

InquilineKea