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Glycolysis by Ms Mithlesh | NORCET 8.0 & 9.0 | Nursing Next Live | NNL ONE | NNL Academy
ะะพะบะฐะทะฐัั ะพะฟะธัะฐะฝะธะต
๐๐จ๐ซ๐ซ๐๐๐ญ ๐๐ง๐ฌ๐ฐ๐๐ซ: ๐. ๐๐ง๐จ๐ฅ๐๐ฌ๐
๐๐๐ญ๐ข๐จ๐ง๐๐ฅ๐:
โข Fluoride oxalate has been suggested to help the preservation of glucose levels. Thus fluoride oxalate has been used over the years to minimize the glycolytic effects of red blood cells (RBC). The fluoride usually exists as sodium fluoride and potassium oxalate (NaF/KOX).
โข Fluoride inhibits enolase, which is far downstream in the glycolytic pathway. Enzymes upstream of enolase remain active and continue to metabolize glucose until substrates are exhausted.
โข The inhibition of glycolysis was accompanied by a decrease in cellular pyruvate and ATP and by accumulation of 2-phosphoenolpyruvate. These results and direct enzymatic determinations showed that fluoride inhibits, in addition to enolase (phosphopyruvate hydratase), also pyruvate kinase.
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โโโโโโโโโโโโโโโโโโโโโ
#norcet8 #norcet2025 #aiimsnorcet2025 #nurse #norcet #norcetexam #undergraduatestudents #bscstudents #nursingaspirants #nursingstudents #reelsinstagram #reelkrofeelkro #reels #nursing #nursingnextlive #nnlone
๐๐๐ญ๐ข๐จ๐ง๐๐ฅ๐:
โข Fluoride oxalate has been suggested to help the preservation of glucose levels. Thus fluoride oxalate has been used over the years to minimize the glycolytic effects of red blood cells (RBC). The fluoride usually exists as sodium fluoride and potassium oxalate (NaF/KOX).
โข Fluoride inhibits enolase, which is far downstream in the glycolytic pathway. Enzymes upstream of enolase remain active and continue to metabolize glucose until substrates are exhausted.
โข The inhibition of glycolysis was accompanied by a decrease in cellular pyruvate and ATP and by accumulation of 2-phosphoenolpyruvate. These results and direct enzymatic determinations showed that fluoride inhibits, in addition to enolase (phosphopyruvate hydratase), also pyruvate kinase.
Stay tuned for more such valuable content! ๐๐
โโโโโโโโโโโโโโโโโโโโโ
#norcet8 #norcet2025 #aiimsnorcet2025 #nurse #norcet #norcetexam #undergraduatestudents #bscstudents #nursingaspirants #nursingstudents #reelsinstagram #reelkrofeelkro #reels #nursing #nursingnextlive #nnlone