25 at 25: Optimising treatments using the ROCI design

Over the 25-year history of the MRC Clinical Trials Unit at UCL, our methodology researchers have pioneered several innovative designs to make randomised clinical trials more efficient and robust. This video in our ‘25 at 25’ series focuses on one such design, called Response Over Continuous Intervention (ROCI).

The ROCI design is used in late-phase trials when an aspect of the treatment is continuous, such as duration, dose or frequency. A continuous treatment implies that there are lots of possible values to test, and we need to select an option that is neither too much nor too little.