Iron Studies - Serum Fe, TIBC, ferritin & Transferrin % Saturation

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Iron Studies - Serum Fe, TIBC, ferritin & Transferrin % Saturation - Part 2

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You have no idea how much this helped me rn. Currently prepping for an exam and of course things begin to get muddled. So thank you so very much.

zainabnasiru

I always thought of the TIBC not at a true number but as an implied number, very much like calculating the "indirect bilirubin. Transferrin can only carry so much iron, & at any given time, transferrin will have some "available" iron binding sites not presently occupied by iron. That is to say, with IDA & low iron everywhere (serum iron, ferritin/storage iron), then the amount of iron being transported on transferrin is also reduced with the resultant increase in the open & available sites. Kind of like there's a finite number of seats on a bus & with fewer passengers there are more empty seats. So, to answer muneeb khwaja's question, IDA means that there are few seats occupied on the transferrin bus (low transferrin saturation) & more seats (TIBC) available.

KCODacey

can we say that> in response to reserve depletion (low ferritine) the liver synthesises more transferin (to grab more iron) and therefore the TIBC increases??

sarahmina

Thank you for the explanation. However many doctors in the UK only test RBC and reluctantly ferritin. If ferritin is low they prescribe additional iron. What you are saying is that without Transferritin saturation you cannot even hope to estimate if that client is truly iron deficient? It is rare that doctors do a full iron panel or even understand how to interpret it. My ferritin has always been low (46 at highest) and often in the twenties yet I have been told (in Australia not the UK!) that my iron saturation was absolutely normal. Clinically though I get symptoms of exhaustion is my ferritin falls into the twenties....so I go of symptoms.

Zoe.TheBody

Maybe I am stupid, but please: what means "Serum iron" I don't get it. Is it the sum of iron in the blood that is bound to transferrin and ferritin? I thought there is no "free iron" in the blood, so what kind of iron is measured when we talk about Serum iron?

levinpyzera

Thank you so much for your efforts
But I gotta say that transferrin and TIBC are not actually the same because for example in IDA the TIBC increases but the transferrin decrease

azzahalfawi

The guy saying he’s tired and pale is a demon from our nightmares

AG-eny

6:34 misinformation, Transferrin has only 2 binding sites for iron also TIBC increases in iron deficiency

hoodoo

This has been very helpful! Thank you!

wonderfulwyoming

I just got results, but can’t see my dr till next week. My Transferrn Saturation is 45%, does that mean Hemachromatosis? I feel like I’m carrying around a bunch of iron literally, I feel heavy. It’s miserable. My Hemoglobin, Hematocrit Bilirubin are borderline high. AST, 175 ALT 184. I always learn more here, so I thought I’d ask. Oh and could medication cause any of this?

carlavegas

TIBC will be high in Iron deficiency anaemia not low . Thx

MohamedNasr-dhwj

So why would someone have a high transferrin saturation and low ferritin, when on testosterone replacement therapy? And high normal total iron.

nicoc

All your videos are outstanding...God bless you .i learned a great deal of work in a short time 😘😘😘🙏🙏🙏

marqarittakakuva

You are amazing .I'm from palestine and you help me .thank you .

ضحىضحى-ته

My results are Iron 27 ug/dL Iron binding capacity, unsaturated 257 ug/dL
Total iron binding capacity 284 ug/dL
Transferrin % saturation 10%
My doctor doesn’t seemed concerned if my results but I’m worried about the low transferrin level.

GaiaGirl