21.8 Michael Reactions | Organic Chemistry

Chad provides a comprehensive lesson on Michael Reactions which involve conjugate or 1,4-addition to a conjugated ketone. A conjugated ketone is referred to as the Michael acceptor and typical Michael donors include the enolate of a beta-diketone and organocuprates (Gilmann reagents). A detailed mechanism with arrow-pushing is included and examples showing how the choice of nucleophile is the distinction of whether 1,2-addition or 1,4-addition occurs.

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00:00 Lesson Introduction
00:50 Michael Reactions: Michael Donors and Acceptors
06:38 Michael Reaction Example
08:48 1,2-Addition vs 1,4-Addition

[megannardi]

Ur a king and the only reason i’m passing orgo 2 !

[medhanshgupta]

wow !! I was really confused about this reaction but its all cleared up now . Your explanations are fantastic . Thank you :)

[GianlucaBerger]

Thank you for posting this, about to take my final next Wednesday and this last chapter is really difficult, but your vids have been super helpful

[Macedonia]

Sir What is reaction between strontium and triphenyl phosphate d15 material.what will becomes final product.pls send the balance equation

[abdalrhmannegm]

Your explanation is fantastic, I wish you all the best

[bartelvanoostendorp]

Thank you! These videos are fantastic!

[varadnerkar]

Does the reaction still proceed if the alpha carbon is substituted with methyl or any alkyl group?

[PunmasterSTP]

Hey, you're a chad! What are you doing talking about betas?