Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

Steve Horvath, PhD, ScD is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health. Dr. Horvath is the creator of the Horvath Epigenetic Aging Clock. His work incorporates elements of biostatistics, genetics, epidemiology, epigenomics, and other fields of study. He applies his understanding of this diverse range of disciplines to study a spectrum of chronic diseases, including cancer, cardiovascular disease, neurodegenerative disease, and other diseases of aging.

Dr. Horvath's so-called "pan-tissue epigenetic aging clock" is an algorithm that accurately predicts a person's chronological age from marks on the DNA across multiple cells, tissues, and organs, and even mammalian species. Further refining this initial algorithm, Dr. Horvath built on this to develop second-generation clock algorithm that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan. One of these clocks, the GrimAge clock, is named deliberately after its connotation: predicting time until death ("Grim").

In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging

EPISODE LINKS:

PODCAST INFO:

Dr. Rhonda Patrick's 3-minute video crash course in epigenetics:

The FoundMyFitness OVERVIEW ARTICLE on epigenetic clocks:

CHAPTERS
00:00:00 - Introductions
00:00:34 - Horvath Aging Clock
00:01:50 - Explaining the error rate
00:06:42 - Hereditary + lifestyle factors
00:15:03 - DNAm PhenoAge vs GrimAge
00:22:50 - Telomere science shortcomings
00:26:08 - Prolonging the epigenetic clock
00:50:56 - Epigenetics: Cause or consequence of aging?
00:56:53 - Vitamin D reverses epigenetic age
00:59:20 - Omega-3 slows down the GrimAge clock
01:04:27 - Ongoing research

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⏳ #aging #longevity #epigenetics 🧬

[FoundMyFitness]

00:00:34 - The Horvath clock explained: Methylation patterns at unique areas of our DNA involved in gene regulation predict a person's age within four to five years.
00:06:42 - The effect of HEREDITY on the epigenetic clock rate (determines as much as 40 percent of rate).
00:12:48 - How the stability of epigenetic information has potential implications in forensic science.
00:26:08 - How diet, exercise, education, and lifestyle factors effect the epigenetic clock.
00:31:59 - How transplanting young cells into an old body may slow epigenetic aging of the recipient.
00:47:23 - Reprogramming pluripotent stem cells by activating specific genes can reset the epigenetic clock.
00:50:56 - Do epigenetic changes drive aging, or are they the result of aging (just the "face of the clock")?
01:02:32 - How poor sleep speeds up the epigenetic clock.
01:12:12 - *Super silly outro easter egg*

This episode has a lot of amazing studies and figures included in the slides, which are available to FoundMyFitness Premium Members, in a convenient presentation! To find out more about becoming a Premium Member, visit:

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[LiveForeverorDieTrying]

Steve is a legend. Thank you for having him on!

[joeamrine]

Definitely one of the most entertaining hours of 2020... awesome idea showing citations for clinicians and researchers who are interested in learning more about these topics!

[MultiGlobalnews]

I don’t really understand when Steve says that a healthy life style doesn’t affect the epigenetic ageing, if that was the case what on earth is David Sinclair doing . I am a tad confused

[davida]

A great interview and guest. I watched it while pedaling on a stationary bicycle. Rhonda is simply a nice human being 😊

[JT-yqbr]

I love the way you add the literature excerpts during the interview. It adds new dimensions to the presentation & gives me new rabbit holes to run toward & through.

[tinox]

thank you so much Rhonda, without people like you we wouldnt bring important topics like aging to the general public. for some reason the average guy doesnt care about aging, only later in life when its already too late. its truly one of the most important topics in the modern times tho

[juliahello]

We evaluated the impact of a 1-year Mediterranean-like diet in a pilot study including 120 elderly healthy subjects from the NU-AGE study (60 Italians, 60 Poles) by measuring the changes in their epigenetic age, assessed by Horvath's clock. We observed a trend towards epigenetic rejuvenation of participants after nutritional intervention.

[colinglen]

Rhonda can hardly contain her excitement! :)

[HighAvenger]

If at 16 years old you stored some of your own bone marrow. Could you in fact store it for long periods of time 10-50 years and then inject your own bone marrow 10-50 years later, would it age while stored? Would it eliminate graph vs host issues if it was your own bone marrow? Just curious.

[FoundMyFitnessClips]

those member benefits... *they're spicy!* 01:12:12 😊

Like and subscribe with notifications on for a ton of great episodes AND FoundMyFitness coming out in the new year. Thank you for watching!

[jreverie]

Your energy and passion gives me the biggest grin possible. I just can’t describe how much appreciation I have for you, your work and the people you interview’s work. On a side note - do you have any books you recommend for someone trying to eat a diet for longevity and health? Thanks Rhonda, hope you’re doing well!

[TheSheekeyScienceShow]

Ah this is so cool, thanks for the interview!! :)

[questlove]

This podcasts follows such a natural but still hardcore biology involved flow, I love it.

[peterz]

Thanks. @32 on parabiosis - recently, the Conboy lab performed a variation (not really parabiosis though) in which 50% of plasma in older mice was replaced with saline and albumin. They saw tissue regeneration in 3 tissues, the liver, muscle, and hippocampus. Lots of changes in many plasma proteins. Would be interesting to know how long this effect persists and if epigenome is affected.

[kenycharles]

I am discovering many instances of people who sleep 5 hours or so, lately.

Thank you for this presentation.
Great interview!

[andidemattos]

Great to see you again Steve. You were my boyfriend's roomate (Rick de Mattos) at UNC CHAPEL HILL over 30 yrs ago! YOU have not AGED MUCH AT ALL YOURSELF! Great interview. Andi Sloan de Mattos. Rick enjoyed seeing you in this video!

[pitapep]

Probably my live-style interventions will not prolong so much my health span but I'm feeling so well that I would continue doing them: 1 or 2 hours exercise outside during sunrise, semi-naked, after 16 hours fasting, CT and two meals a day high-fat low carb.

[dr.samierasadoonalhassani]

Thank you both for sharing such level of interesting information which usually kept in the labs..Thank you and may God bless you in your biological age of longevity and wellness.

[IrisDemarco]

Speaking of age, why is there an old rotary phone sitting on the desk ? Other than that, very advanced ground breaking information. Fascinating!!!