This video is actually VERY helpful. I was lost with cdk and cyclines function and now they make perfect sense! Thank you.
thalesmatzkeit
thank you so much for your unselfish deeds
elfili
I’m a mantle cell lymphoma patient and this is of tremendous interest to me. MCL occurs (almost always) due to a chromosome translocation which place the cyclin-d gene right after the immunoglobulin h genes. Too much cyclin-d is produced in my B lymphocytes and the cell cycle is disregulated. I reckon that groovy P21 protein just can’t handle the cyclin-d overload!
richardomer
This is awesome! thanks for putting this together
kobleezy
Very productive video that helped me ALOT..Thanks allot dmflyboy....
naveedkhankakar
wow! great video. please keep on with your videos, they are very helpful.
Bbita
Very useful and clear explanation. Thank you!
kianazsara
awesome explanations! i wish i had you for biochemistry
TheWs
Thanks for that was a very useful introduction :)
davidvreugdenhil
Thanks...I teach this course every Fall. Updates will be posted then.
dmflyboy
The diagram in the first half of the video is great. Is there anywhere online I could find it?
atay
thanks for your interest... I use Camtasia software.
dmflyboy
Since mutations in the retinoblastomas are recessive (Rb is a tumor suppressor gene), it is rare that individuals inherit a mutation from both parents, so the occurrence of a retinoblastoma tumor is a stochastic event in each eye. there is no guarantee that a heterozygote will develop a tumor in both eyes.
Thanks for your interest!
dmflyboy
Hello, I really like your way to explain. I have question, Can you please tell me which program did you use in explanation in YouTube. Thank you.
yousefalrajhi
very good and useful videos! may I ask what video editing software you use?
rhcorr
great video and thank you so much for sharing your knowledge. I have 1 question. In some books it says that p21 inhibits cdk2 could you clarify if this is the case or does p21 inhibits cyclin D as you stated in the video.
MrBbb
doesn't hereditary intrinsic mutation of retinoblastoma lead to two tumorous eyes and spontaneous extrinsic mutation result in one eye or am i interpreting knudson's two hit model incorrectly? Thorough video nonetheless
percentoxygen
hey! great video! :) may I know who is the narrator in the video and is this video under an incorporated publisher? Thanks a lot! :)
Brensek
Is it just me or did his shirt change colour halfway through?
MyNo
I thought that Cyclin D is continuously present throughout the cell cycle
