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#MRCP PART ONE#PASSMEDICINE 2020 Basic Science 9
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Keys of Basic Science
UPPER LIMB ANATOMY
RADIAL NERVE
ULNAR NERVE
LOWER LIMB ANATOMY
POPLITEAL FOSSA
RENAL ANATOMY
FORAMINA OF THE SKULL
CRANIAL NERVES
SPINAL CORD
BRACHIAL PLEXUS
DERMATOMES
COLLAGEN
CELL ORGANELLES
CELL CYCLE
CELL DIVISION
MICROTUBULES
MEMBRANE RECEPTORS
CELL SURFACE PROTEINS
MUSCLE CONTRACTION
TROPONIN
SECOND MESSENGERS
CARDIOVASCULAR PHYSIOLOGY
CARDIAC ACTION POTENTIAL
ATRIAL NATRIURETIC PEPTIDE
NITRIC OXIDE
ENDOTHELIN
RESPIRATORY PHYSIOLOGY
RESPIRATORY PHYSIOLOGY: CONTROL
RESPIRATORY PHYSIOLOGY: LUNG COMPLIANCE
RESPIRATORY PHYSIOLOGY: HYPOXIA
PULMONARY SURFACTANT
GASTROINTESTINAL HORMONES
RENAL PHYSIOLOGY
RENIN
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
ERYTHROPOIESIS
GROWTH HORMONE
ANTIDIURETIC HORMONE
PROLACTIN
ADRENAL MEDULLA
CEREBRAL PERFUSION PRESSURE
ALKALINE PHOSPHATASE
ARACHIDONIC ACID METABOLISM
IRON METABOLISM
FOLATE METABOLISM
CALCIUM METABOLISM
VITAMIN B1 (THIAMINE)
VITAMIN B2 (RIBOFLAVIN)
VITAMIN B3 (NIACIN)
VITAMIN B6 (PYRIDOXINE)
VITAMIN C (ASCORBIC ACID)
VITAMIN C DEFICIENCY (SCURVY)
VITAMIN D
RICKETS
VITAMIN D-RESISTANT RICKETS
VITAMIN K
IMMUNE SYSTEM CELLS: INNATE IMMUNE RESPONSE
IMMUNE SYSTEM CELLS: ADAPTIVE IMMUNE RESPONSE
IMMUNOGLOBULINS
T-HELPER CELLS
CYTOKINES
IL-1
INTERFERON
LEUKOTRIENES
ACUTE PHASE PROTEINS
HYPERSENSITIVITY
MOLECULAR BIOLOGY TECHNIQUES
POLYMERASE CHAIN REACTION
OBESITY: PHYSIOLOGY
SLEEP STAGES
PENETRANCE AND EXPRESSIVITY
ANTIBIOTICS: MECHANISM OF ACTION
ANTIBIOTICS: PROTEIN SYNTHESIS INHIBITORS
ANAESTHETIC AGENTS
LOCAL ANAESTHETIC AGENTS
MUSCLE RELAXANTS
POST OPERATIVE FLUID MANAGEMENT
POTASSIUM SPARING DIURETICS
FIBRATES
EZETIMIBE
BREASTFEEDING: CONTRAINDICATIONS
MITOCHONDRIAL DISEASES
COMPLEMENT DEFICIENCIES
PARATHYROID GLANDS AND DISORDERS OF CALCIUM METABOLISM
HUNGRY BONE SYNDROME
DISORDERS OF SEX HORMONES
TURNER’S SYNDROME
METABOLIC ALKALOSIS
HYPOCALCAEMIA: FEATURES
HYPOCALCAEMIA: CAUSES AND MANAGEMENT
HYPERCALCAEMIA: MANAGEMENT
HYPONATRAEMIA
HYPONATRAEMIA: TREATMENT
94
SIADH: CAUSES
95
HYPERNATRAEMIA
HYPOKALAEMIA
HYPOKALAEMIA AND HYPERTENSION
PSEUDOHYPERKALAEMIA
HYPERKALAEMIA
HYPERURICAEMIA
HYPOPHOSPHATAEMIA
HLA ASSOCIATIONS
AUTOSOMAL DOMINANT
AUTOSOMAL DOMINANT CONDITIONS
FAMILIAL HYPERCHOLESTEROLAEMIA
ACHONDROPLASIA
AUTOSOMAL RECESSIVE CONDITIONS
CYSTIC FIBROSIS
CYSTIC FIBROSIS: FEATURES
CYSTIC FIBROSIS: MANAGEMENT
GALACTOSAEMIA
HOMOCYSTINURIA
PHENYLKETONURIA
ALKAPTONURIA
ANDERSON-FABRY DISEASE
X-LINKED DOMINANT
X-LINKED RECESSIVE
X-LINKED RECESSIVE CONDITIONS
ALPHA-THALASSAEMIA
DISSEMINATED INTRAVASCULAR COAGULATION
CHILDHOOD SYNDROMES
FRAGILE X SYNDROME
NOONAN SYNDROME
PRADER-WILLI SYNDROME
WILLIAM’S SYNDROME
DIGEORGE SYNDROME
MCCUNE-ALBRIGHT SYNDROME
DOWN’S SYNDROME: EPIDEMIOLOGY AND GENETICS
DOWN’S SYNDROME: FEATURES
HIRSCHSPRUNG’S DISEASE
TRINUCLEOTIDE REPEAT DISORDERS
INHERITED METABOLIC DISORDERS
CONGENITAL HEART DISEASE: TYPES
PATENT DUCTUS ARTERIOSUS
TETRALOGY OF FALLOT
TRANSPOSITION OF THE GREAT ARTERIES
EBSTEIN’S ANOMALY
ATHEROSCLEROSIS
HYPERLIPIDAEMIA: SECONDARY CAUSES
HYPERLIPIDAEMIA: MANAGEMENT
DIABETIC NEPHROPATHY
MUCORMYCOSIS
URINARY CASTS
RENAL TUBULAR ACIDOSIS
RENAL STONES
EXOTOXINS AND ENDOTOXINS
STAPHYLOCOCCI
ESCHERICHIA COLI
CAMPYLOBACTER
MYCOBACTERIUM MARINUM
CONGENITAL INFECTIONS
CHILDHOOD INFECTIONS
DIARRHOEA IN CHILDREN
CHICKENPOX
MEASLES
HAND, FOOT AND MOUTH DISEASE
ENTEROVIRUSES
SCARLET FEVER
BRONCHIOLITIS
CROUP
HERPES SIMPLEX VIRUS
HIV: IMMUNOLOGY
HIV: THE VIRUS
ACUTE EPIGLOTTITIS
CHOLANGITIS
POST-SPLENECTOMY SEPSIS
MECKEL’S DIVERTICULUM
APPENDICITIS IN CHILDREN
PYLORIC STENOSIS
RICKETTSIAE
HELMINTHS
WUCHERERIA BANCROFTI
THREADWORMS
CUTANEOUS LARVA MIGRANS
KNEE PROBLEMS: CHILDREN AND YOUNG ADULTS
KAWASAKI DISEASE
ONCOGENES
TUMOUR SUPPRESSOR GENES
p53
WILMS’ TUMOUR
CNS TUMOURS
BRAIN TUMOURS
ACUTE TUBULAR NECROSIS
TEMPORAL ARTERY BIOPSY
FITNESS TO FLY
STATISTICAL TERMS: DESCRIPTIVE STATISTICS
CONFIDENCE INTERVAL AND STANDARD ERROR OF THE MEAN
VARIANCE
NORMAL DISTRIBUTION
SKEWED DISTRIBUTIONS
PRE- AND POST- TEST ODDS AND PROBABILITY
ODDS AND ODDS RATIO
HAZARD RATIO
RELATIVE RISK
NUMBERS NEEDED TO TREAT AND ABSOLUTE RISK REDUCTION
RELIABILITY AND VALIDITY
BIAS
FUNNEL PLOT
CONFOUNDING
CORRELATION AND LINEAR REGRESSION
SCREENING TEST STATISTICS
DATA TYPES
CLINICAL TRIAL: PHASES
STUDY DESIGN
STUDY DESIGN: EVIDENCE AND RECOMMENDATIONS
STUDY DESIGN: NEW DRUGS
SIGNIFICANCE TESTS
SIGNIFICANCE TESTS: TYPES
INTENTION TO TREAT ANALYSIS
SCREENING: WILSON AND JUNGER CRITERIA
INCIDENCE AND PREVALENCE
GMC GUIDANCE: CONFIDENTIALITY
PATIENTS WHO REFUSE TREATMENT
UPPER LIMB ANATOMY
RADIAL NERVE
ULNAR NERVE
LOWER LIMB ANATOMY
POPLITEAL FOSSA
RENAL ANATOMY
FORAMINA OF THE SKULL
CRANIAL NERVES
SPINAL CORD
BRACHIAL PLEXUS
DERMATOMES
COLLAGEN
CELL ORGANELLES
CELL CYCLE
CELL DIVISION
MICROTUBULES
MEMBRANE RECEPTORS
CELL SURFACE PROTEINS
MUSCLE CONTRACTION
TROPONIN
SECOND MESSENGERS
CARDIOVASCULAR PHYSIOLOGY
CARDIAC ACTION POTENTIAL
ATRIAL NATRIURETIC PEPTIDE
NITRIC OXIDE
ENDOTHELIN
RESPIRATORY PHYSIOLOGY
RESPIRATORY PHYSIOLOGY: CONTROL
RESPIRATORY PHYSIOLOGY: LUNG COMPLIANCE
RESPIRATORY PHYSIOLOGY: HYPOXIA
PULMONARY SURFACTANT
GASTROINTESTINAL HORMONES
RENAL PHYSIOLOGY
RENIN
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
ERYTHROPOIESIS
GROWTH HORMONE
ANTIDIURETIC HORMONE
PROLACTIN
ADRENAL MEDULLA
CEREBRAL PERFUSION PRESSURE
ALKALINE PHOSPHATASE
ARACHIDONIC ACID METABOLISM
IRON METABOLISM
FOLATE METABOLISM
CALCIUM METABOLISM
VITAMIN B1 (THIAMINE)
VITAMIN B2 (RIBOFLAVIN)
VITAMIN B3 (NIACIN)
VITAMIN B6 (PYRIDOXINE)
VITAMIN C (ASCORBIC ACID)
VITAMIN C DEFICIENCY (SCURVY)
VITAMIN D
RICKETS
VITAMIN D-RESISTANT RICKETS
VITAMIN K
IMMUNE SYSTEM CELLS: INNATE IMMUNE RESPONSE
IMMUNE SYSTEM CELLS: ADAPTIVE IMMUNE RESPONSE
IMMUNOGLOBULINS
T-HELPER CELLS
CYTOKINES
IL-1
INTERFERON
LEUKOTRIENES
ACUTE PHASE PROTEINS
HYPERSENSITIVITY
MOLECULAR BIOLOGY TECHNIQUES
POLYMERASE CHAIN REACTION
OBESITY: PHYSIOLOGY
SLEEP STAGES
PENETRANCE AND EXPRESSIVITY
ANTIBIOTICS: MECHANISM OF ACTION
ANTIBIOTICS: PROTEIN SYNTHESIS INHIBITORS
ANAESTHETIC AGENTS
LOCAL ANAESTHETIC AGENTS
MUSCLE RELAXANTS
POST OPERATIVE FLUID MANAGEMENT
POTASSIUM SPARING DIURETICS
FIBRATES
EZETIMIBE
BREASTFEEDING: CONTRAINDICATIONS
MITOCHONDRIAL DISEASES
COMPLEMENT DEFICIENCIES
PARATHYROID GLANDS AND DISORDERS OF CALCIUM METABOLISM
HUNGRY BONE SYNDROME
DISORDERS OF SEX HORMONES
TURNER’S SYNDROME
METABOLIC ALKALOSIS
HYPOCALCAEMIA: FEATURES
HYPOCALCAEMIA: CAUSES AND MANAGEMENT
HYPERCALCAEMIA: MANAGEMENT
HYPONATRAEMIA
HYPONATRAEMIA: TREATMENT
94
SIADH: CAUSES
95
HYPERNATRAEMIA
HYPOKALAEMIA
HYPOKALAEMIA AND HYPERTENSION
PSEUDOHYPERKALAEMIA
HYPERKALAEMIA
HYPERURICAEMIA
HYPOPHOSPHATAEMIA
HLA ASSOCIATIONS
AUTOSOMAL DOMINANT
AUTOSOMAL DOMINANT CONDITIONS
FAMILIAL HYPERCHOLESTEROLAEMIA
ACHONDROPLASIA
AUTOSOMAL RECESSIVE CONDITIONS
CYSTIC FIBROSIS
CYSTIC FIBROSIS: FEATURES
CYSTIC FIBROSIS: MANAGEMENT
GALACTOSAEMIA
HOMOCYSTINURIA
PHENYLKETONURIA
ALKAPTONURIA
ANDERSON-FABRY DISEASE
X-LINKED DOMINANT
X-LINKED RECESSIVE
X-LINKED RECESSIVE CONDITIONS
ALPHA-THALASSAEMIA
DISSEMINATED INTRAVASCULAR COAGULATION
CHILDHOOD SYNDROMES
FRAGILE X SYNDROME
NOONAN SYNDROME
PRADER-WILLI SYNDROME
WILLIAM’S SYNDROME
DIGEORGE SYNDROME
MCCUNE-ALBRIGHT SYNDROME
DOWN’S SYNDROME: EPIDEMIOLOGY AND GENETICS
DOWN’S SYNDROME: FEATURES
HIRSCHSPRUNG’S DISEASE
TRINUCLEOTIDE REPEAT DISORDERS
INHERITED METABOLIC DISORDERS
CONGENITAL HEART DISEASE: TYPES
PATENT DUCTUS ARTERIOSUS
TETRALOGY OF FALLOT
TRANSPOSITION OF THE GREAT ARTERIES
EBSTEIN’S ANOMALY
ATHEROSCLEROSIS
HYPERLIPIDAEMIA: SECONDARY CAUSES
HYPERLIPIDAEMIA: MANAGEMENT
DIABETIC NEPHROPATHY
MUCORMYCOSIS
URINARY CASTS
RENAL TUBULAR ACIDOSIS
RENAL STONES
EXOTOXINS AND ENDOTOXINS
STAPHYLOCOCCI
ESCHERICHIA COLI
CAMPYLOBACTER
MYCOBACTERIUM MARINUM
CONGENITAL INFECTIONS
CHILDHOOD INFECTIONS
DIARRHOEA IN CHILDREN
CHICKENPOX
MEASLES
HAND, FOOT AND MOUTH DISEASE
ENTEROVIRUSES
SCARLET FEVER
BRONCHIOLITIS
CROUP
HERPES SIMPLEX VIRUS
HIV: IMMUNOLOGY
HIV: THE VIRUS
ACUTE EPIGLOTTITIS
CHOLANGITIS
POST-SPLENECTOMY SEPSIS
MECKEL’S DIVERTICULUM
APPENDICITIS IN CHILDREN
PYLORIC STENOSIS
RICKETTSIAE
HELMINTHS
WUCHERERIA BANCROFTI
THREADWORMS
CUTANEOUS LARVA MIGRANS
KNEE PROBLEMS: CHILDREN AND YOUNG ADULTS
KAWASAKI DISEASE
ONCOGENES
TUMOUR SUPPRESSOR GENES
p53
WILMS’ TUMOUR
CNS TUMOURS
BRAIN TUMOURS
ACUTE TUBULAR NECROSIS
TEMPORAL ARTERY BIOPSY
FITNESS TO FLY
STATISTICAL TERMS: DESCRIPTIVE STATISTICS
CONFIDENCE INTERVAL AND STANDARD ERROR OF THE MEAN
VARIANCE
NORMAL DISTRIBUTION
SKEWED DISTRIBUTIONS
PRE- AND POST- TEST ODDS AND PROBABILITY
ODDS AND ODDS RATIO
HAZARD RATIO
RELATIVE RISK
NUMBERS NEEDED TO TREAT AND ABSOLUTE RISK REDUCTION
RELIABILITY AND VALIDITY
BIAS
FUNNEL PLOT
CONFOUNDING
CORRELATION AND LINEAR REGRESSION
SCREENING TEST STATISTICS
DATA TYPES
CLINICAL TRIAL: PHASES
STUDY DESIGN
STUDY DESIGN: EVIDENCE AND RECOMMENDATIONS
STUDY DESIGN: NEW DRUGS
SIGNIFICANCE TESTS
SIGNIFICANCE TESTS: TYPES
INTENTION TO TREAT ANALYSIS
SCREENING: WILSON AND JUNGER CRITERIA
INCIDENCE AND PREVALENCE
GMC GUIDANCE: CONFIDENTIALITY
PATIENTS WHO REFUSE TREATMENT