Pyruvate Kinase Deficiency | Hemolytic Anemia

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0:30 Glycolysis
0:59 Pyruvate kinase deficiency
3:21 Extravascular hemolysis
3:33 Clinical Manifestations
3:44 Diagnosis
4:49 Treatment

iamgopz
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Treatment now includes the drug Mitapivat (Pyrukynd). It activates the PK enzyme

zach
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Ah hamd le allah actually you are help me in my presentation for tomorrow thank you (nursing college in saudi arebia ) I hope from allah to help you in your life and make you good moslem🙏🏻

soharam
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My final yr med exam in due tomorrow. Thanks for such a short and informative video. 🙏🏻

s.u.k.k.u
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I do not understand - if there is no ATP, how can any cell survive - lest rbc?

egroegny
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I'm happy 😍
Love you medicosis
You're the best ..the smart egyptian doctor ❤

ItsMe-jrkd
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Thanx sir
But there is no mitochondia in RBCs

fareedfityan
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Can someone please mention what are the hemolytic anemia in intravascular and extravascular totally please

ponnurangamdivya
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Both loss of water and gain of water is possible in this disease...in some individuals theres dehydration leading to echinocytes while in other theres gain of water leading to spherocytosis.

Apratim
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Why haptogloblin is low b/c here it is hemolysis then there should be low hemopexin ? kindly clear it @medicosis Perfectionalis

dr.maaira
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Medicosis my boy... Love this... You are yet to release myelodysplatic syndrome though...

drpepper
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Pls make video on Myelodysplastic syndromes

jamieemcclary
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Fantastic...
Ok sir ...
I have a question.. can IDA be hemolysis type ?? And what type of hemolysis can be ???
Please answer me...

alial_iraqi
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if the pathology is intracorpuscular why is the mechanism of hemolysis extravascular?

DermaineJESHUABROWN
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How does the dehydration of RBCs occur?

tawhibnoman
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Sir please tell me why hemoglobin levels are low in pyruvate kinase deficiency..even though it is an hemolytic anemia

familygyyshorts
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Hi medicosis please : why we have an increase of NADH/NAD Ratio in case of pyruvate kinase defiency ??

ItsMe-jrkd
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