Lecture 4c: T Cell Signaling + Activation

UCSD Extension School: Applied Immunology (BIOL-40371)
Spring Quarter 2021
This lecture summarizes the signal transduction mechanisms that occur downstream of T cell receptor binding to a cognate antigen:MHC complex, and how these contribute to the cellular state known as T cell activation.

All figures are either from Janeway's Immunobiology (9th ed.) where noted, or my own original figures.

[shellodee]

I have been looking for a video explanation of the T Cell activation processes as clear as this for the last 7 years. My son was born with ORAI1 deficiency and passed away in 2017. I knew what went wrong and could explain to someone who had no idea, but i wanted to know exactly where in the activation process it went wrong. Thank you. Amazing that through all the genetic coding that goes in to one human being, all it takes is the substitution of 1 letter twice in one gene to catastrophically collapse it all. . .

[kiomi]

Thank you for your clear explanation! This is great :)

[tnbn]

Hi! Thank you for your videos. Just wanted to point out that kinases attach phosphate groups from ATP as opposed from free phosphate. Phosphorylases are the one that utilize free phosphate.

[aryandraarya]

Will be interesting to see if TCR can detect difference in epitopes at subatomic levels like replacing the H with deuterium or changing the stereochemistry of amino acids. GPCR for olfaction in drosophila can do that. If TCR can do it, this opens up a new field of research for autoimmunity. Damn I need funding for this project.! Btw should have included kinetic segregation model.

[adnanrahman]

mam your seapking pluency is so fast thtas why we face diffeculties in geting your words can you make another vedio in liitle slow