Hereditary Angioedema (HAE)

- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....

Hereditary angioedema (HAE) causes increases bradykinin causing angioedema, dry cough, abdominal pain, ...etc.

Bradykinin is produced from high molecular weight kininogen (HMWK) via plasma kallikrein.
High molecular weight kininogen is a plasma protein (alpha globulin) responsible for activating the intrinsic coagulation pathway as well as producing the inflammatory mediator known as bradykinin (via plasma kallikrein).

Plasma kallikrein, in addition to high molecular weight kininogen (HMWK), is responsible for activating factor XII into XIIa.

Kallikrein-Kinin system consists of a kallikrein (plasma kallikrein or tissure kallikrein) producing a kinin (bradykinin in the plasma and kallidin in the tissue).

Angiotensin-converting enzyme (ACE) degrades bradykinin into inactive metabolites.

Books that I use for this series:

[sotogunx]

Thank you so much for posting these videos!I know you won't see this but you help thousands of doctors

[stefanronning]

The 5 ads on a ten minute video triggered an attack

[kelseyparker]

Loved this video! I have HAE myself and I really enjoyed finding out all the different types and why it occurs!

[windygail]

Thank you for sharing this! Im going through the ups and downs of getting diagnosed with something as rare as this. This helped me understand a bit more than reading up on it.

[OsamaHJT]

Really came here for a single piece of information but ended up watching the whole video. You have a very interesting and unique way of presenting subjects, I had to subscribe.

[liliyakamala]

I have this and a additional seven (clinically determined) so called extremely rare diagnoses (according to the Swedish state medical/social department.
I also get my heart muscle swelling when this strikes.

[amirasaied]

I miss ur awesome videos cause I have exams, hello from Egypt

[olganesicilic]

Brilliant lecture!
Greetings from Serbia!

[eclecticism]

It is so fun to watch your videos. Your accent is sweet so as your style and the animations!

[ahmedelsakka]

so C1 esterase inhibitor has no role in deactivation complement cascade ? you haven't mention anything about that topic

[MusaMindset]

Hurry up and put the next video up, my exam is in couple of weeks. Thank you for your hard work 🤝

[mrlilducky]

BCRX got FDA approved for their medication to treat HAE

[medschoolpowerpoints]

Thank you for such a great explanation 😊🙌💕✨

[argumentumadbaculum]

Why is hereditary angioedema painless if bradykinin is high

[johnmccullough]

Are there any adaptations that occur with continued exposure to high levels of Bradykinin and HAE attacks? Does the body learn or adapt to exposures to Bradykinin to reduce the frequency or severity of attacks?

[jamesmartinreyes]

I have eyes swollens everytime i have a fever. And when i drink medicine its swollen

[basheeroudahus]

Thanks for sharing ... by the way I saw those Wind Turbine Generators seen in the video in my way between Qum and Tehran city , just before two weeks .

[kirasays]

I’ve been tested for this 2 years ago after having swollen tongue and lips 2 weeks later and nothing came back that this is hereditary for me so I must be the first? Idk this is confusing but I’ve had 4-5 episodes of swelling. First time was 2 years ago when my tongue swelled and a week later my lips swelled. Didn’t happen again until this month when my hand was swollen, then random large hives all over my body, then my lips again.

[samarsamar]

Blood test for engiodema please reply me iam so worried

[thor]

Sir mujhe bhi swelling hoti h full body me na hi kahi se aram mila h das saal se kya aap meri madad kar sakte ho