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WG Seminars: Feng, Predicting Respirable Aerosols Using Virtual Humans, September 7, 2023
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Predicting Health Endpoints for Respirable Aerosols using Multiscale CFPD-PBPK/TK/PD Virtual Human Model
Yu Feng
School of Chemical Engineering
Oklahoma State University
The interaction between respirable aerosolized particulate matter (e.g., aerosolized medications for inhalation therapy and airborne transmissible viruses) and the human respiratory system is a complex process that spans multiple spatial and temporal scales. This presentation will introduce the research efforts done by Dr. Yu Feng’s lab on the developments in the coupling of computational fluid-particle dynamics (CFPD) simulations with Physiologically Based Pharmacokinetic/Toxicokinetic/Pharmacodynamic (PBPK/TK/PD) models to capture the journey of aerosols from emission to lung transport/deposition, systemic translocation, and potential body responses. A key aspect of this integration is using CFPD to predict the transport and deposition of inhaled particulate matter. This approach contributes to the PBPK/TK/PD model by accounting for patient-specific and disease-specific variabilities, enhancing its accuracy. The integrated framework offers a noninvasive and cost-effective tool for inhalation dosimetry, complementing traditional in vitro and in vivo experiments. The CFPD-PBPK/TK/PD modeling framework can provide a noninvasive, cost-effective, and time-saving inhalation dosimetry tool, which will significantly help accelerate the revolution in pulmonary healthcare and occupational exposure risk assessment, e.g., innovation in lung disease diagnosis, inhalation therapy, and toxic aerosol exposure risk mitigation. Three examples will be presented in this webinar: (1) Emission and Transmission: Predicting the airborne transmission of virus-laden droplets in various indoor environments between individuals. (2) Transport and Deposition in the Lung: Estimating the administered dose of inhaled aerosols using an elastic whole-lung model, and (3) After-Deposition Dynamics (Host-Cell Dynamics): Forecasting the transport, deposition, and immune responses triggered by inhaled Influenza A virus and nasal spray vaccine droplets.
*Contents*
00:00 - Introductory Material
05:45 - Yu Feng: Predicting Health Endpoints for Respirable Aerosols using Multiscale CFPD-PBPK/TK/PD Virtual Human Model
46:55 - Questions
Yu Feng
School of Chemical Engineering
Oklahoma State University
The interaction between respirable aerosolized particulate matter (e.g., aerosolized medications for inhalation therapy and airborne transmissible viruses) and the human respiratory system is a complex process that spans multiple spatial and temporal scales. This presentation will introduce the research efforts done by Dr. Yu Feng’s lab on the developments in the coupling of computational fluid-particle dynamics (CFPD) simulations with Physiologically Based Pharmacokinetic/Toxicokinetic/Pharmacodynamic (PBPK/TK/PD) models to capture the journey of aerosols from emission to lung transport/deposition, systemic translocation, and potential body responses. A key aspect of this integration is using CFPD to predict the transport and deposition of inhaled particulate matter. This approach contributes to the PBPK/TK/PD model by accounting for patient-specific and disease-specific variabilities, enhancing its accuracy. The integrated framework offers a noninvasive and cost-effective tool for inhalation dosimetry, complementing traditional in vitro and in vivo experiments. The CFPD-PBPK/TK/PD modeling framework can provide a noninvasive, cost-effective, and time-saving inhalation dosimetry tool, which will significantly help accelerate the revolution in pulmonary healthcare and occupational exposure risk assessment, e.g., innovation in lung disease diagnosis, inhalation therapy, and toxic aerosol exposure risk mitigation. Three examples will be presented in this webinar: (1) Emission and Transmission: Predicting the airborne transmission of virus-laden droplets in various indoor environments between individuals. (2) Transport and Deposition in the Lung: Estimating the administered dose of inhaled aerosols using an elastic whole-lung model, and (3) After-Deposition Dynamics (Host-Cell Dynamics): Forecasting the transport, deposition, and immune responses triggered by inhaled Influenza A virus and nasal spray vaccine droplets.
*Contents*
00:00 - Introductory Material
05:45 - Yu Feng: Predicting Health Endpoints for Respirable Aerosols using Multiscale CFPD-PBPK/TK/PD Virtual Human Model
46:55 - Questions