Diffuse Large B-Cell Lymphoma (DLBCL) - Aggressive B-Cell Neoplasm - Non-Hodgkin’s Lymphoma

Diffuse Large B-Cell Lymphoma (DLBCL) - Aggressive B-Cell Neoplasm - Non-Hodgkin’s Lymphoma

Hematological malignancies are subdivided into leukemias, lymphomas, and multiple myeloma.

Lymphoma can be Hodgkin or Non-Hodgin's (such as DLBCL).

Diffuse Large B-cell lymphoma (DLBCL) is an aggressive Non-Hodgkin's lymphoma (NHL)...It's the most common NHL

To diagnose, you need a core needle biopsy or an excisional biopsy of the lymph node

Uric acid levels can be high---Give allopurinol (Xanthine oxidase inhibitor).

Staging of cancer is important (Ann-Arbor classification based on history, physical exam and CT scan)

Treatment: Combination Chemotherapy (R-CHOP) regimen.

Tumor lysis syndrome can ensue.

PET scan is helpful.

The lymph node is a bean-shaped body (not a gland) that interrupts the flow of lymph through the lymphatic vessels.

Afferent lymphatics go towards the lymph node, while efferent exits the node. The lymph node has cortex (which contains the follicle, germinal center, mantle, and margin).

Lymphocyte activation and differentiation occur in the lymph node.

Lymph is a colorless fluid that floats in the lymphatic vessels (lymphatics) of your lymphatic systems.

Formed from the interstitial fluid (extracellular fluid) and returns back to the big veins (Superior vena cava) through the thoracic duct and Right lymphatic duct.

Lymph slows down when it passes in lymph nodes.

Lacteals are a special type of lymph, they are milky because they contain chylomicrons.

Lymph node enlargement can happen in cases of lymphoma (painless lymphadenopathy) or infection (painful).

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[tooneboone]

I am an 83 yr male- I had DLBCL when I was 61yrs old, had my spleen out and CHOP chem. -it was back 12 yrs later and I had RCHOP - back 7 yrs later more RCHOP - back again 3yrs and I am still fighting!

[Bee]

This is a very good explanation! Thank you! My mother is 93 and was just diagnosed with DLBCL. Her left foot was swelling up. Numerous doctors visits and then 1 night her entire left swelled up. I took her to the ER and they found a mass encasing her iliac arteries and urterer. Biopsy took 1 week to get results. She had Rituxan and 2 days later chemo. She was sent home. Swelling is starting to go down finally. She also had a nephrostomy to help her left kidney drain into a bag. At 1st doctors were very grim. When they asked me her activity level and I told them she walks 4 miles a day, runs and dances twice a week, they decided try treatments to see if her body would tolerate them. So far so good!

[yikotao]

hi, i find your lectures really useful. Most of the lectures tell the difference in individual topic and do not differentiate from the outline and tell u where is the disease in the general part, which is absolutely confusing. Thanks for your uploading and sharing!

[amandabrown]

39yrs old, fem. In beginning of 2024 got diagnosed as well. Im in middle of 6 rounds of my R Chop chemotherapy. Have stage 2 High Grade Diffuse large B-cell Lymphoma. Aggressive type. It was in my inguinal area/inner right thigh. Was so uncomfortable, it was hard to sit or walk & another small one on the left. This video has helped my husband & I to fully understand when I was first diagnosed.🙏❤

[Exodiaright]

For there was both side lymphadenopathy of diaphragm, but not involving extranodal area, stage III was indicated.

[AttackMaster]

my girlfriend who is 20y/o was diagnosed a few months ago with large b cell lymphoma. she just finished treatment today!

[tahiransari]

Both side off diaphram one lymph node from mediastinum and other from inguinal and illiac lymph node involment stage 3

[manarmhs]

Stage 3a : more than one group of lymph node is affected and it is below and above the diaphragm

[laurapm]

stage IV because the mass is in the mediastinum, and you have multiple l.n in the inguinal and iliac (so we supose it's disseminated).

[Anits]

Thank you l have large diffuse B cell non hodgekins lymphoma and I’m doing 6 rounds of R-CHOP chemotherapy. All of my blood tests are normal. I’m 35 and was just diagnosed. Mine is in my right lung and localized to my chest. I have an enlarged lymph node in my chest as well. My oncologist has me on allopurinol for uric acid.

[rubymusqan]

i have been watching ur hematology and oncology playlist for few days, i'm a second year medical student, these videos really help a lot and they are very amazing. also, a request- i have pathology as my subject in 2nd year so it would be nice if u also add morphology of cells in all of your videos. :)

[elpibeheyzoos]

Cant say im here bwcause i was only curious. Im 23 and Have been going to an oncologist because a cardiovascular surgeon diagnosed me with bilateral lymphadema. Stating it was a biproduct of something else. Now im getting tested for NHL, had a biopsy 4 days ago and just waiting for the results in 3 days. Video definitely helped me understand a lot more. Thank you

[zainulaabdeen]

My Father, 73 year old recently got diagnosed with DLBCL high grade.

[nm_arts]

My father 63 yrs, diagnosed with dlbcl stage 3 in 2014, , treated with RCHOP, remission in 2015, relapsed in oct 2021, , now doc is treating with RGDP, , but this time its getting very tough for him to cope, chemo has made him too weak 😔

[summaiyafathima]

Stage3: 2 or more lymph node on opposite side of diaphragm.

[khizarakg]

Kindly mention the IHC markers for diagnosing DLBCL

[kohwaian]

What is some of the causes of this disease? What is the cause of the imbalances of the T cells and B cells? Why are these cells not communicating with each other?

[jacopobersellini]

Hi,
Loving your videos! I find them very helpful.
But at 4:02 you say that a performance status less or equal than 2 is a unfavourbale prognostic factor. Should't it be the opposite?

[muntadhralsuwela]

stage 3 due to both side of the diaphragm involvement and with only lymph node involvement

[takyc]

is it not performance status score >2 instead of below at 4:00