Autism Genes | Genes Involved in the Development of Autism

Autism Genes | Genes Involved in the Development of Autism
#Autism #AutismGenes #TheDisordersCare

everal psychiatric diseases have strong evidences of genetic involvement in their origin, and among them are schizophrenia, bipolar disturbance and autism. In 1977, a study with mono and dizygotic twins described for the first time the genetic predisposition of autism [26,27].

Nowadays, population studies suggest that the model that better describes DASs is multifactorial [13,20,28,29] with a concordance of 60-92% in monozygotic twins and 0-10% in dizygotic twins [30]. Differences found in studies between monozygotic twins support the multifactorial model, demonstrating the importance of environmental factors.

Several studies were performed to clarify genetic factors associated with the disease. Autism symptoms that suggest a strong genetic component are convulsions, mental deficiency, neurons and synapse decrease in amygdala, hippocampus and cerebellum, increased size of encephalon, and increased level of circulating serotonin. Even studies with monozygotic twins show a significant concordance, as opposed to dizygotic twins. Non-twin siblings present a risk of developing autism ranging from 0-30%, and this risk is much higher than in the general population [31].

The comparison of the mentioned populational groups, as well as the difference between men and women, shows epistatic effects (hierarchy between alleles) that involve an interaction between several genes, suggesting the role of environmental factors [32].

The Disorders care is a researched base small group that is dedicated to provide the necessary information relating disorders for parents and guardians of challenged kids so that not only they can timely identify the disorder and but also so that they can take better care of their children.