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Single Molecule Sequencing: Epigenomics
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Instructors: Theodore M. Nelson, Christopher E. Mason
Lecture Summary: Epigenomics provides a key avenue for understanding biological aging and difference. There are many diverse biological phenotypes which have been directly tied to CPG islets and DNA epigenomic modifications. Additionally, this lecture includes a discussion of HW2.
Course Summary: Sequencing-based research has become the dominant investigative practice within the biological sciences. Single-molecule sequencing: training, methods, and applications, responds to this development by providing a hands-on and in-depth introduction to sequencing for students, from Sanger to third-generation technologies. Utilizing an alternating lecture-lab schedule, students are introduced to fundamental basic principles of DNA & RNA science, progressing to cutting-edge library preparation and sequencing analysis techniques with Illumina and Nanopore technologies. Students will have the opportunity to perform direct-RNA sequencing samples on research samples, and experience first-hand the ethical implications of this data. Relevant concepts in biology and computer science will be addressed.
Relevant Papers:
Lecture Summary: Epigenomics provides a key avenue for understanding biological aging and difference. There are many diverse biological phenotypes which have been directly tied to CPG islets and DNA epigenomic modifications. Additionally, this lecture includes a discussion of HW2.
Course Summary: Sequencing-based research has become the dominant investigative practice within the biological sciences. Single-molecule sequencing: training, methods, and applications, responds to this development by providing a hands-on and in-depth introduction to sequencing for students, from Sanger to third-generation technologies. Utilizing an alternating lecture-lab schedule, students are introduced to fundamental basic principles of DNA & RNA science, progressing to cutting-edge library preparation and sequencing analysis techniques with Illumina and Nanopore technologies. Students will have the opportunity to perform direct-RNA sequencing samples on research samples, and experience first-hand the ethical implications of this data. Relevant concepts in biology and computer science will be addressed.
Relevant Papers: