This Company is Resurrecting the Mammoth

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Colossal Biosciences is a biotechnology company that has gained attention for its ambitious projects, particularly its efforts to bring extinct species back to life, or "de-extinction." Founded in 2021, the company is based in the United States and has set its sights on reviving species such as the woolly mammoth and the Tasmanian tiger (thylacine). The concept of de-extinction involves using genetic engineering technologies, including CRISPR, to modify the DNA of living relatives of extinct species so that they resemble the extinct species more closely.

Colossal's approach to the woolly mammoth, for example, involves editing the genome of Asian elephants, which are the closest living relatives of mammoths, to introduce traits characteristic of mammoths. These traits include thick fur, fat layers, and other adaptations that allowed mammoths to survive in cold environments. The ultimate goal is to create elephant-mammoth hybrids that could live in Arctic environments, which could potentially help restore the grasslands of the mammoth steppe ecosystem and combat climate change by preventing permafrost melt.

The company is also exploring the potential for applying its genetic technologies to conservation efforts for endangered species, suggesting that the tools developed for de-extinction could also be used to increase genetic diversity and resilience in species facing extinction threats.

Colossal has attracted significant media attention and investment, raising questions about the ethical, ecological, and practical implications of de-extinction. Critics of de-extinction argue that resources could be better spent on conserving existing species and ecosystems, while proponents believe that the technology represents an innovative approach to conservation and could bring ecological benefits.

Colossal Biosciences represents a cutting-edge intersection of genetics, conservation, and technology, highlighting both the potential and the challenges of using biotechnology to address environmental issues.

Timestamps:

00:00 Intro
01:20 Extinction rates
02:40 The founders of Colossal
05:10 How does it work?
06:45 How do you birth them?
07:30 Ethics
08:50 Outro
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