Overview of recent changes to the treatment landscape for HER2-positive CRC

John Strickler, MD, Duke University, Durham, NC discusses recent changes to the treatment landscape for HER2-positive colorectal cancer (CRC). The recent approval of trastuzumab deruxtecan across all solid tumors, and particularly for patients with CRC with the highest level of expression of HER2, known as IHC3+, has been significant. It complements the tucatinib and trastuzumab regimen from the MOUNTAINEER trial (NCT03043313), which was approved for both IHC2+ and IHC3+ types HER2-positive CRC and showed long term response in IHC2+ disease. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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