That sinking feeling

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[johnsimun]

Millions of neurons in the gastrointestinal tract coordinate their activity to generate the muscle contractions that propel waste through the last leg of the digestive system, according to a study of isolated mouse colons published in JNeurosci. The newly identified neuronal firing pattern may represent an early feature preserved through the evolution of nervous systems.

The enteric nervous system (ENS) is known as the "second brain" or the brain in the gut because it can operate independently of the brain and spinal cord, the central nervous system (CNS). It has also been called the "first brain" based on evidence suggesting that the ENS evolved before the CNS. Despite the known role of the ENS in generating motor activity in the colon, observing ENS neurons in action has been a challenge.

Nick Spencer and colleagues combined a new neuronal imaging technique with electrophysiology records of smooth muscle to reveal a pattern of activity that involves many different types of neurons firing simultaneously in repetitive bursts to activate the muscle cells at the same rate. They demonstrate how this rhythmic activity generates so-called colonic migrating motor complexes to transport fecal pellets through the mouse colon. These findings identify a previously unknown pattern of neuronal activity in the peripheral nervous system.

[AkilanNarayanaswamy]

RIP to the person that called Louis before this video went up 😂

[guiorgy]

Since I am extremely bad at being social, I don't need to see a number, just getting a phone call makes me go "Ah sh*t, here we go again..."

[tensei_alter]

Makes sense to me. Don't let people you don't like live in your head rent-free.

[GamerTime_]

Louis, you may say you're not a good person, but you have tenacity, and that's inspiring.

[NaptownClassic]

Everyone who called Louis recently is wondering, "Am I the sinking feeling person he's talking about?"

[stanimir]

Learning to be direct and say no/reject is a useful skill.

[johnchristopher]

No one ever calls unless it's bad news. If it's good news, it's in an email and 3 months late.

[rhadek]

Gotta be careful, because that gut feeling will definitely lie to you sometimes. But if it keeps happening over a longer period you should probably listen to it.

[Cut_to_the_chase_man]

For more than 10 years my wife could never understand why I hated my phone ringing. I'd swear and curse every time it rang. It wasn't until she got a job where she was on call that she understood.

[dragenoxinside]

Louis' life is a freaking rollercoaster, it went from "we're starting to win!", to "that sinking feeling" real quick.

[pcsecuritychannel]

That's a really good point. Sometimes we are more aware subconsciously than we are consciously, and taking those signals can save months or years of time in getting to the proper response.

[TerkanTyr]

Imagine calling Louis today, not getting thorough, and then you see this video pop up a few hours later.

Now *that* would definitely be one of those sinking feelings lol.

[IAMDEH]

This is why:
A- My phone's always on silent mode.
B- I rarely answer phone calls if I don't recognize the number.
C- I do not answer the phone if I know I'm gonna get that feeling.

[bernicegoldham]

I think that's an extremely level-headed approach to difficult interactions with difficult people. At this point I view sanity as a virtue and that strategy fits the bill.

[TheFarCobra]

I had a group of “friends” like that a few years ago. Expunging them from my life was the best thing I ever did. It was also the hardest thing I ever did as they represented the majority of my friends at that time. But, you know what? I made new friends, much better friends.

[Platinum_Tugboat]

In a bid to get sober, i've literally cut everyone out of my life. I used to get those feelings like you do, but now no one calls me.. its awesome and lonely too, hard to make friends because im terrified im gonna relapse.. so I avoid people and potential friends..

[gvulture]

The time when we didn't all have phones is very nostalgic because people who could give you sinking feeling had to get to a landline or phone booth (and had to hope you were home at the same time) or come right to your door and no one had time for that.

[ConnorG]

I totally agree with you! Getting toxic people out of your life, even if it is hard, is important for everyone's mental health. The ways that they negatively effect you each time they call you aren't worth putting up with for long. Time is better spent doing activities you enjoy and interacting with people that give you those good feelings!

[SnrubEvad]

Most people treat a ringing phone like a fire alarm that they must deal with. Just stop answering the phone unless YOU actually want to talk to them. Let them leave a message, then you can listen without getting wrapped up into the drama.